Neuropsychological outcomes following HSCT in MS: A systematic review

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dc.check.date2025-06-15en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorDavenport, Lauraen
dc.contributor.authorMcCauley, Mathewen
dc.contributor.authorBreheny, Erinen
dc.contributor.authorSmyth, Liamen
dc.contributor.authorGaughan, Mariaen
dc.contributor.authorTubridy, Niallen
dc.contributor.authorMcGuigan, Chrisen
dc.contributor.authorO'Keeffe, Fiadhnaiten
dc.date.accessioned2024-12-10T11:14:42Z
dc.date.available2024-12-10T11:14:42Z
dc.date.issued2024-06-15en
dc.description.abstractBackground: Autologous haematopoietic stem cell transplant (HSCT) is considered an effective treatment for highly active multiple sclerosis (MS). To date, most research has focused primarily on disease outcome measures, despite the significant impact of neuropsychological symptoms on MS patients’ quality of life. The current systematic review aimed to examine whether HSCT for MS impacts neuropsychological outcome measures such as cognition, fatigue, mood, and quality of life. Methods: The review was registered with the International Prospective Register of Systematic Reviews (PROSPERO, ID: CRD42023474214). Systematic searches were carried out in six databases (PsycINFO, PubMed, Embase, Scopus, CINAHL and Web of Science) based on the following inclusion criteria: (i) published in peer-reviewed journals in English; (ii) longitudinal studies of adults with MS (iii) at least one neuropsychological outcome was assessed pre- and post-HSCT using standardised measures. Risk of bias was assessed using the National Heart, Lung and Blood Institute (NHLBI) quality assessment tools. A narrative synthesis was used to present results. Results: Eleven studies were included in the review. Long-term improvements in quality of life post-HSCT were identified. In terms of cognition and fatigue, the evidence was mixed, with some post-HSCT improvements identified. Decline in cognitive performance in the short-term post-HSCT was observed. No changes in mood were identified post-HSCT. Arguments for interpreting these results with caution are presented based on risk of bias. Arguments for interpreting these results with caution are presented based on risk of bias. Limitations of the evidence are discussed, such confounding variables and lack of statistical power. Conclusion: The evidence base for the impact of HSCT for MS on neuropsychological outcomes is limited. Further research is required to progress understanding to facilitate clinician and patient understanding of HSCT treatment for MS.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid105702en
dc.identifier.citationDavenport, L., McCauley, M., Breheny, E., Smyth, L., Gaughan, M., Tubridy, N., McGuigan, C. and O'Keeffe, F. (2024) 'Neuropsychological outcomes following HSCT in MS: A systematic review', Multiple Sclerosis and Related Disorders, 88. 105702 (10pp). https://doi.org/10.1016/j.msard.2024.105702en
dc.identifier.doihttps://doi.org/10.1016/j.msard.2024.105702en
dc.identifier.endpage10en
dc.identifier.issn2211-0348en
dc.identifier.journaltitleMultiple Sclerosis and Related Disordersen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/16717
dc.identifier.volume88en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.ispartofMultiple Sclerosis and Related Disordersen
dc.rights© 2024, Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMultiple sclerosisen
dc.subjectHaematopoietic stem cell transplanten
dc.subjectNeuropsychologyen
dc.subjectNeuropsychological outcomesen
dc.subjectPatient-reported outcomesen
dc.titleNeuropsychological outcomes following HSCT in MS: A systematic reviewen
dc.typeArticle (peer-reviewed)en
oaire.citation.volume88en
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