Born this way: Hippocampal neurogenesis across the lifespan

Simple item page
dc.contributor.authorKozareva, Danka A.
dc.contributor.authorCryan, John F.
dc.contributor.authorNolan, Yvonne M.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-09-09T08:56:40Z
dc.date.available2019-09-09T08:56:40Z
dc.date.issued2019-09-02
dc.description.abstractThe capability of the mammalian brain to generate new neurons through the lifespan has gained much attention for the promise of new therapeutic possibilities especially for the aging brain. One of the brain regions that maintains a neurogenesis-permissive environment is the dentate gyrus of the hippocampus. Here, new neurons are generated from a pool of multipotent neural progenitor cells to become fully functional neurons that are integrated into the brain circuitry. A growing body of evidence points to the fact that neurogenesis in the adult hippocampus is necessary for certain memory processes, and in mood regulation, while alterations in hippocampal neurogenesis have been associated with a myriad of neurological and psychiatric disorders. More recently, evidence has come to light that new neurons may differ in their vulnerability to environmental and disease-related influences depending on the time during the life course at which they are exposed. Thus, it has been the topic of intense research in recent years. In this review, we will discuss the complex process and associated functional relevance of hippocampal neurogenesis during the embryonic/postnatal period and in adulthood. We consider the implications of hippocampal neurogenesis during the developmentally critical periods of adolescence and older age. We will further consider the literature surrounding hippocampal neurogenesis and its functional role during these critical periods with a view to providing insight into the potential of harnessing neurogenesis for health and therapeutic benefit.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide13007en
dc.identifier.citationKozareva, D. A., Cryan, J. F. and Nolan, Y. M. (2019) 'Born this way: Hippocampal neurogenesis across the lifespan', 18(5), e13007 (18pp.). DOI: 10.1111/acel.13007en
dc.identifier.doi10.1111/acel.13007en
dc.identifier.eissn1474-9726
dc.identifier.endpage18en
dc.identifier.issn1474-9718
dc.identifier.issued5en
dc.identifier.journaltitleAging Cellen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8467
dc.identifier.volume18en
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IA/1537/IE/The nuclear receptor TLX as a cell intrinsic regulator underlying inflammation and stress-induced changes in hippocampal neurogenesis: relevance to cognitive disorders/en
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/acel.13007
dc.rights© 2019 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAdolescenceen
dc.subjectAgingen
dc.subjectHippocampusen
dc.subjectLifespanen
dc.subjectMemoryen
dc.subjectMooden
dc.subjectNeurogenesisen
dc.titleBorn this way: Hippocampal neurogenesis across the lifespanen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kozareva_et_al-2019-Aging_Cell.pdf
Size:
849.34 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
APC Microbiome Ireland - Journal Articles
Anatomy and Neuroscience - Journal Articles