The composition of human milk and infant faecal microbiota over the first three months of life: a pilot study

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dc.contributor.authorMurphy, Kiera
dc.contributor.authorCurley, David
dc.contributor.authorO'Callaghan, Tom F.
dc.contributor.authorO'Shea, Carol Anne
dc.contributor.authorDempsey, Eugene M.
dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorRoss, R. Paul
dc.contributor.authorRyan, C. Anthony
dc.contributor.authorStanton, Catherine
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2017-03-01T09:04:32Z
dc.date.available2017-03-01T09:04:32Z
dc.date.issued2017-01-17
dc.date.updated2017-02-27T10:39:26Z
dc.description.abstractHuman milk contains a diverse array of bioactives and is also a source of bacteria for the developing infant gut. The aim of this study was to characterize the bacterial communities in human milk and infant faeces over the first 3 months of life, in 10 mother-infant pairs. The presence of viable Bifidobacterium and Lactobacillus in human milk was also evaluated. MiSeq sequencing revealed a large diversity of the human milk microbiota, identifying over 207 bacterial genera in milk samples. The phyla Proteobacteria and Firmicutes and the genera Pseudomonas, Staphylococcus and Streptococcus were the predominant bacterial groups. A core of 12 genera represented 81% of the microbiota relative abundance in milk samples at week 1, 3 and 6, decreasing to 73% at week 12. Genera shared between infant faeces and human milk samples accounted for 70-88% of the total relative abundance in infant faecal samples, supporting the hypothesis of vertical transfer of bacteria from milk to the infant gut. In addition, identical strains of Bifidobacterium breve and Lactobacillus plantarum were isolated from the milk and faeces of one mother-infant pair. Vertical transfer of bacteria via breastfeeding may contribute to the initial establishment of the microbiota in the developing infant intestine.en
dc.description.sponsorshipDepartment of Agriculture, Food and Marine (INFANTMET Project, Grant Number 10/RDT/MFRC/705); Science Foundation Ireland (APC Microbiome Institute Grant Number SFI/12/RC/2273)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid40597
dc.identifier.citationMurphy, K., Curley, D., O’Callaghan, T.F., O’Shea, C.A., Dempsey, E.M., O’Toole, P.W., Ross, R.P., Ryan, C.A. and Stanton, C. (2017) ‘The composition of human milk and infant faecal microbiota over the first three months of life: a pilot study’, Scientific Reports, 7, 40597 (10pp). doi:10.1038/srep40597en
dc.identifier.doi10.1038/srep40597
dc.identifier.endpage10en
dc.identifier.issn2045-2322
dc.identifier.journaltitleScientific Reportsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/3711
dc.identifier.volume7en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2017, the Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBreast-milken
dc.subjectBacterial diversityen
dc.subjectGuten
dc.subjectFecesen
dc.subjectNewbornsen
dc.subjectDeliveryen
dc.subjectDiseaseen
dc.subjectHealthen
dc.subjectCellsen
dc.subjectWomenen
dc.titleThe composition of human milk and infant faecal microbiota over the first three months of life: a pilot studyen
dc.typeArticle (peer-reviewed)en
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