Partial Restriction. Restriction lift date: 2027-05-31
Development of rapid analytical separation methods for the detection of NSAIDs in wastewater
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Date
2023
Authors
Alatawi, Hanan
Journal Title
Journal ISSN
Volume Title
Publisher
University College Cork
Published Version
Abstract
Recently, non-steroidal anti-inflammatory drugs (NSAIDs) have been increasingly used in humans and animals. Despite being effective against a wide variety of diseases, they pose a threat to aquatic environments. Since NSAIDs are poorly degraded and highly water-soluble, they are able to pass through all-natural filtration processes. It has been well known that conventional wastewater treatment plants (WWTPs) were not made to completely remove these compounds because they were not intended to do so. As a result, several pharmaceuticals are released back into the environment. It is essential to develop fast, simple, and reliable analytical methods for detecting NSAIDs in environmental water.
Capillary electrophoresis (CE) has been used for many years to determine various classes of pharmaceuticals in various sample matrices due to its advantages of high separation efficiency and rapid analysis time. The interest in CE has led to the miniaturization of microchip electrophoresis (ME). ME has advantages over traditional analysis techniques, such as fast separation, high separation efficiency, low reagent volume, decreased waste generation, and low-power requirement (the maximum voltage that can be used is 3 kV), and its potential of portability and disposability.
The goal of this project was to develop novel methods for rapid separation and detection of NSAIDs in wastewater using capillary and microchip electrophoresis with UV and C4D detections. The methods were validated using solid phase extraction(SPE), and two different cartridges (C18 and Oasis HLB) were optimized to enhance the recoveries. The results of the research project showed that NSAIDs compounds could be well separated in less than 1 min and had excellent analytical performances with LODs ranging between 0.125 and 0.5 mg/L. The microchip system has proved to be an excellent analytical technique for fast and reliable environmental applications.
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Partial Restriction
Keywords
Non-steroidal anti-inflammatory drugs (NSAIDs) , Capillary electrophoresis , Microchip electrophoresis , Capacitively coupled contactless conductivity detection , Environmental water , Microfluidics , Solid phase extraction
Citation
Alatawi, H. M. 2023. Development of rapid analytical separation methods for the detection of NSAIDs in wastewater. PhD Thesis, University College Cork.