Development of rapid analytical separation methods for the detection of NSAIDs in wastewater

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dc.check.chapterOfThesisChapter one pg( 1-89) and chapter five pg(195-217)en
dc.check.date2027-05-31
dc.check.infoPartial Restriction
dc.contributor.advisorMoore, Eric
dc.contributor.authorAlatawi, Hananen
dc.contributor.funderSaudi Arabian Cultural Bureauen
dc.date.accessioned2024-01-24T12:31:14Z
dc.date.available2024-01-24T12:31:14Z
dc.date.issued2023en
dc.date.submitted2023
dc.descriptionPartial Restriction
dc.description.abstractRecently, non-steroidal anti-inflammatory drugs (NSAIDs) have been increasingly used in humans and animals. Despite being effective against a wide variety of diseases, they pose a threat to aquatic environments. Since NSAIDs are poorly degraded and highly water-soluble, they are able to pass through all-natural filtration processes. It has been well known that conventional wastewater treatment plants (WWTPs) were not made to completely remove these compounds because they were not intended to do so. As a result, several pharmaceuticals are released back into the environment. It is essential to develop fast, simple, and reliable analytical methods for detecting NSAIDs in environmental water. Capillary electrophoresis (CE) has been used for many years to determine various classes of pharmaceuticals in various sample matrices due to its advantages of high separation efficiency and rapid analysis time. The interest in CE has led to the miniaturization of microchip electrophoresis (ME). ME has advantages over traditional analysis techniques, such as fast separation, high separation efficiency, low reagent volume, decreased waste generation, and low-power requirement (the maximum voltage that can be used is 3 kV), and its potential of portability and disposability. The goal of this project was to develop novel methods for rapid separation and detection of NSAIDs in wastewater using capillary and microchip electrophoresis with UV and C4D detections. The methods were validated using solid phase extraction(SPE), and two different cartridges (C18 and Oasis HLB) were optimized to enhance the recoveries. The results of the research project showed that NSAIDs compounds could be well separated in less than 1 min and had excellent analytical performances with LODs ranging between 0.125 and 0.5 mg/L. The microchip system has proved to be an excellent analytical technique for fast and reliable environmental applications.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlatawi, H. M. 2023. Development of rapid analytical separation methods for the detection of NSAIDs in wastewater. PhD Thesis, University College Cork.
dc.identifier.endpage234
dc.identifier.urihttps://hdl.handle.net/10468/15434
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectSaudi Arabian Cultural Bureau (IR 18183)
dc.rights© 2023, Hanan Alatawi.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNon-steroidal anti-inflammatory drugs (NSAIDs)
dc.subjectCapillary electrophoresis
dc.subjectMicrochip electrophoresis
dc.subjectCapacitively coupled contactless conductivity detection
dc.subjectEnvironmental water
dc.subjectMicrofluidics
dc.subjectSolid phase extraction
dc.titleDevelopment of rapid analytical separation methods for the detection of NSAIDs in wastewateren
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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