STOPP/START criteria for potentially inappropriate medications/potential prescribing omissions in older people: uptake and clinical impact

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dc.check.date45635en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorMcGettigan, Siobhánen
dc.contributor.authorCurtin, Denisen
dc.contributor.authorO’Mahony, Denisen
dc.date.accessioned2024-02-06T16:48:42Z
dc.date.available2024-02-06T16:48:42Z
dc.date.issued45269en
dc.description.abstractIntroduction: STOPP/START criteria for potentially inappropriate medications (PIMs, STOPP) and potential prescribing omissions (PPOs, START) have gained considerable interest and traction since they were first published in 2008. This review focuses on their uptake and impact in various clinical settings. Areas covered: STOPP/START criteria, now in their third iteration, are explicit criteria designed to facilitate detection of common and clinically important PIMs and PPOs during routine medication review in any clinical setting. We examine the influence of the criteria, particularly in clinical trials that focused on their impact on clinically relevant endpoints. Expert opinion: STOPP/START criteria are widely used in several countries within Europe and beyond for medication review and audit. As a discreet intervention, the criteria have been tested in several single-center and two large-scale multi-center clinical trials. The single-center trials indicate that STOPP/START criteria reduce polypharmacy, inappropriate prescribing, ADRs (adverse drug reactions), medication cost and falls. In contrast, the SENATOR and OPERAM multicentre trials did not demonstrate significant reduction in ADRs, all-cause mortality, drug-related hospital readmissions, nor any improvement in quality-of-life. Further clinical trials are required to examine whether STOPP/START criteria as an intervention can deliver significant clinical benefit in a reproducible manner in various clinical settings.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMcGettigan, S., Curtin, D. and O’Mahony, D. (2023) 'STOPP/START criteria for potentially inappropriate medications/potential prescribing omissions in older people: uptake and clinical impact', Expert Review of Clinical Pharmacology, 16(12), pp. 1175-1185. doi: https://doi.org/10.1080/17512433.2023.2280219en
dc.identifier.doi10.1080/17512433.2023.2280219en
dc.identifier.eissn1751-2441en
dc.identifier.endpage1185en
dc.identifier.issn1751-2433en
dc.identifier.issued12en
dc.identifier.journaltitleExpert Review of Clinical Pharmacologyen
dc.identifier.startpage1175en
dc.identifier.urihttps://hdl.handle.net/10468/15505
dc.identifier.volume16en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.rights© 2023, Taylor & Francis Group, LLC. This is an Accepted Manuscript of an item published by Taylor & Francis in Expert Review of Clinical Pharmacology on 9 December 2023, available online: https://doi.org/10.1080/17512433.2023.2280219. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectPolypharmacyen
dc.subjectSTOPP/START criteriaen
dc.subjectOlder peopleen
dc.subjectAdverse drug eventsen
dc.subjectMedication reviewen
dc.subjectMultimorbidityen
dc.subjectDeprescribingen
dc.subjectInappropriate prescribingen
dc.titleSTOPP/START criteria for potentially inappropriate medications/potential prescribing omissions in older people: uptake and clinical impacten
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue12en
oaire.citation.volume16en
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