Alterations of haemodynamic parameters in spontaneously hypertensive rats by Aristolochia ringens Vahl. (Aristolochiaceae)

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dc.contributor.authorAigbe, Flora Ruth
dc.contributor.authorMunavvar, Abdul Sattar Zubaid
dc.contributor.authorRathore, Hassan
dc.contributor.authorEseyin, Olorunfemi
dc.contributor.authorPei, Yen Pei
dc.contributor.authorAkhtar, Safia
dc.contributor.authorChohan, Ashfaq
dc.contributor.authorJin, Hui
dc.contributor.authorKhoo, Jooli
dc.contributor.authorTan, Samual
dc.contributor.authorLazhari, Mohammed
dc.contributor.authorAfzar, Sheryar
dc.contributor.authorAhmed, Fiaz
dc.contributor.authorAdeyemi, Olufunmilayo Olaide
dc.contributor.authorJohns, Edward J.
dc.contributor.funderUniversity of Lagos, Nigeria
dc.date.accessioned2017-05-03T10:15:23Z
dc.date.available2017-05-03T10:15:23Z
dc.date.issued2017-02
dc.date.updated2017-05-03T09:17:29Z
dc.description.abstractAristolochia ringens Vahl. (Aristolochiaceae (AR); 馬兜鈴 mǎ dōu líng) is used traditionally in Nigeria for the management of various disorders including oedema. Preliminary investigation revealed its modulatory effect on the cardiovascular system. This study was aimed at investigating the effect of the aqueous root extract of A. ringens (AR) on haemodynamic parameters of spontaneously hypertensive rats (SHRs). The effect of oral subacute (21 days) and intravenous acute exposure of SHRs to the extract were assessed using tail cuff and carotid artery canulation methods respectively. In the latter, the effect of chloroform, butanol and aqueous fractions of AR were also evaluated. The extract significantly reduced systolic and diastolic blood pressures in SHRs, with peak reductions of 20.3% and 26.7% respectively at 50 mg/kg by the 21st day of oral subacute exposure. Upon intravenous exposure, AR (50 mg/kg) reduced systolic and diastolic blood pressure by as much as 53.4 ± 2.2 and 49.2 ± 2.8 mmHg respectively. A dose-dependent reduction in heart rate, significant at 25 and 50 mg/kg was also observed. Hexamethonium (20 mg/kg) and atropine (1 mg/kg) inhibited the extract's reduction of systolic blood pressure, diastolic blood pressure and heart rate significantly. The extract's butanol fraction produced the greatest systolic and diastolic blood pressures reduction of 67.0 ± 3.8 and 68.4 mmHg respectively at 25 mg/kg and heart rate reduction of 40 ± 7 beats per minute at 50 mg/kg. HPLC analysis revealed the presence of 4-hydroxybenzoic acid and quercetin in AR. The extract's alterations of haemodynamic parameters in this study show that it has hypotensive effect on spontaneously hypertensive rats.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAigbe, F. R., Munavvar, A. S. Z., Rathore, H., Eseyin, O., Pei, Y. P., Akhtar, S., Chohan, A., Jin, H., Khoo, J., Tan, S., Lazhari, M., Afzar, S., Ahmed, F., Adeyemi, O. O. and Johns, E. J. (2017) 'Alterations of haemodynamic parameters in spontaneously hypertensive rats by Aristolochia ringens Vahl. (Aristolochiaceae)', Journal of Traditional and Complementary Medicine, 8(1), pp. 72-80. doi: 10.1016/j.jtcme.2017.02.006en
dc.identifier.doi10.1016/j.jtcme.2017.02.006
dc.identifier.endpage80
dc.identifier.issn2225-4110
dc.identifier.issued1
dc.identifier.journaltitleJournal of Traditional and Complementary Medicineen
dc.identifier.startpage72
dc.identifier.urihttps://hdl.handle.net/10468/3908
dc.identifier.volume8
dc.language.isoenen
dc.publisherElsevier Ltd on behalf of the Center for Food and Biomolecules, National Taiwan Universityen
dc.relation.projectUniversity of Lagos, Nigeria (Doctoral Research Grant)en
dc.rights© 2017 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.en
dc.rights.urihttp://creativecommons.org/ licenses/by-nc-nd/4.0/en
dc.subjectAristolochia ringensen
dc.subjectAqueous extracten
dc.subjectSpontaneously hypertensive ratsen
dc.subjectPhenolicsen
dc.subjectButanol fractionen
dc.titleAlterations of haemodynamic parameters in spontaneously hypertensive rats by Aristolochia ringens Vahl. (Aristolochiaceae)en
dc.typeArticle (peer-reviewed)en
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