Oral cancer incidence and survival rates in the Republic of Ireland, 1994-2009
| dc.contributor.author | Ali, Hala | |
| dc.contributor.author | Sinnott, Sarah-Jo | |
| dc.contributor.author | Corcoran, Paul | |
| dc.contributor.author | Deady, Sandra E. | |
| dc.contributor.author | Sharp, Linda | |
| dc.contributor.author | Kabir, Zubair | |
| dc.date.accessioned | 2017-01-04T15:00:21Z | |
| dc.date.available | 2017-01-04T15:00:21Z | |
| dc.date.issued | 2016-12-20 | |
| dc.date.updated | 2017-01-04T14:51:18Z | |
| dc.description.abstract | Background: Oral cancer is a significant public health problem world-wide and exerts high economic, social, psychological, and physical burdens on patients, their families, and on their primary care providers. We set out to describe the changing trends in incidence and survival rates of oral cancer in Ireland between 1994 and 2009. Methods: National data on incident oral cancers [ICD 10 codes C01-C06] were obtained from the National Cancer Registry Ireland from 1994 to 2009. We estimated annual percentage change (APC) in oral cancer incidence during 1994–2009 using joinpoint regression software (version 4.2.0.2). The lifetime risk of oral cancer to age 79 was estimated using Irish incidence and population data from 2007 to 2009. Survival rates were also examined using Kaplan-Meier curves and Cox proportional hazard models to explore the influence of several demographic/lifestyle covariates with follow-up to end 2012. Results: Data were obtained on 2,147 oral cancer incident cases. Men accounted for two-thirds of oral cancer cases (n = 1,430). Annual rates in men decreased significantly during 1994–2001 (APC = -4.8 %, 95 % CI: −8.7 to −0.7) and then increased moderately (APC = 2.3 %, 95 % CI: −0.9 to 5.6). In contrast, annual incidence increased significantly in women throughout the study period (APC = 3.2 %, 95 % CI: 1.9 to 4.6). There was an elevated risk of death among oral cancer patients who were: older than 60 years of age; smokers; unemployed or retired; those living in the most deprived areas; and those whose tumour was sited in the base of the tongue. Being married and diagnosed in more recent years were associated with reduced risk of death. Conclusion: Oral cancer increased significantly in both sexes between 1999 and 2009 in Ireland. Our analyses demonstrate the influence of measured factors such as smoking, time of diagnosis and age on observed trends. Unmeasured factors such as alcohol use, HPV and dietary factors may also be contributing to increased trends. Several of these are modifiable risk factors which are crucial for informing public health policies, and thus more research is needed. | en |
| dc.description.sponsorship | Department of Epidemiology and Public Health, University College Cork | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Ali, H., Sinnott, S.-J., Corcoran, P., Deady, S., Sharp, L. and Kabir, Z. (2016) 'Oral cancer incidence and survival rates in the Republic of Ireland, 1994-2009', BMC Cancer, 16(1), 950 (7 pp). doi:10.1186/s12885-016-2839-3 | en |
| dc.identifier.doi | 10.1186/s12885-016-2839-3 | |
| dc.identifier.endpage | 950-7 | en |
| dc.identifier.issn | 1471-2407 | |
| dc.identifier.issued | 1 | en |
| dc.identifier.journaltitle | BMC Cancer | en |
| dc.identifier.startpage | 950-1 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/3423 | |
| dc.identifier.volume | 16 | en |
| dc.language.iso | en | en |
| dc.publisher | BioMed Central | en |
| dc.rights | © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Oral cancer | en |
| dc.subject | Incidence rate | en |
| dc.subject | Survival rate | en |
| dc.subject | Joinpoint regression | en |
| dc.subject | Time trend | en |
| dc.title | Oral cancer incidence and survival rates in the Republic of Ireland, 1994-2009 | en |
| dc.type | Article (peer-reviewed) | en |
