Designer bacteria as intratumoural enzyme biofactories
dc.contributor.author | Lehouritis, Panos | |
dc.contributor.author | Hogan, Glenn | |
dc.contributor.author | Tangney, Mark | |
dc.contributor.funder | Irish Cancer Society | en |
dc.contributor.funder | Science Foundation Ireland | en |
dc.contributor.funder | Breakthrough Cancer Research, Ireland | en |
dc.date.accessioned | 2017-10-05T10:32:58Z | |
dc.date.available | 2017-10-05T10:32:58Z | |
dc.date.issued | 2017-09-12 | |
dc.date.updated | 2017-10-05T09:30:12Z | |
dc.description.abstract | Bacterial-directed enzyme prodrug therapy (BDEPT) is an emerging form of treatment for cancer. It is a biphasic variant of gene therapy in which a bacterium, armed with an enzyme that can convert an inert prodrug into a cytotoxic compound, induces tumour cell death following tumour-specific prodrug activation. BDEPT combines the innate ability of bacteria to selectively proliferate in tumours, with the capacity of prodrugs to undergo contained, compartmentalised conversion into active metabolites in vivo. Although BDEPT has undergone clinical testing, it has received limited clinical exposure, and has yet to achieve regulatory approval. In this article, we review BDEPT from the system designer's perspective, and provide detailed commentary on how the designer should strategize its development de novo. We report on contemporary advancements in this field which aim to enhance BDEPT in terms of safety and efficacy. Finally, we discuss clinical and regulatory barriers facing BDEPT, and propose promising approaches through which these hurdles may best be tackled. | en |
dc.description.sponsorship | Irish Cancer Society (PCI12TAN); | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Lehouritis, P., Hogan, G. and Tangney, M. (2017) 'Designer bacteria as intratumoural enzyme biofactories', Advanced Drug Delivery Reviews, In Press. doi:10.1016/j.addr.2017.09.012 | en |
dc.identifier.doi | 10.1016/j.addr.2017.09.012 | |
dc.identifier.endpage | 16 | en |
dc.identifier.issn | 0169-409X | |
dc.identifier.journaltitle | Advanced Drug Delivery Reviews | en |
dc.identifier.startpage | 1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/4835 | |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Career Development Award/15/CDA/3630/IE/Edible Probiotics As Cancer Theranostics/ | en |
dc.relation.project | info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/612219/EU/Vaccines and Imaging Partnership/VIP | en |
dc.relation.uri | http://www.sciencedirect.com/science/article/pii/S0169409X1730193X | |
dc.rights | © 2017 Elsevier B.V. This manuscript version is made available under the CC BY-NC-ND 4.0 license. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Tumour | en |
dc.subject | DEPT | en |
dc.subject | Prodrug | en |
dc.subject | Cancer | en |
dc.subject | Chemotherapy | en |
dc.subject | Drug design | en |
dc.subject | Synthetic biology | en |
dc.subject | Targeted | en |
dc.subject | Translational research | en |
dc.subject | R&D | en |
dc.title | Designer bacteria as intratumoural enzyme biofactories | en |
dc.type | Article (peer-reviewed) | en |