Characterization and modeling of acousto-optic signal strengths in highly scattering media

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dc.contributor.authorBengtsson, Alexander
dc.contributor.authorHill, David
dc.contributor.authorLi, Meng
dc.contributor.authorDi, Mengqiao
dc.contributor.authorCinthio, Magnus
dc.contributor.authorErlöv, Tobias
dc.contributor.authorAndersson-Engels, Stefan
dc.contributor.authorReistad, Nina
dc.contributor.authorWalther, Andreas
dc.contributor.authorRippe, Lars
dc.contributor.authorKröll, Stefan
dc.contributor.funderKnut och Alice Wallenbergs Stiftelseen
dc.contributor.funderLunds Tekniska Högskola, Lunds universiteten
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-10-26T06:35:50Z
dc.date.available2019-10-26T06:35:50Z
dc.date.issued2019-09-07
dc.description.abstractUltrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.en
dc.description.sponsorshipKnut and Alice Wallenberg Foundation (KAW 2016.0081, KAW 2017.0449 and Wallenberg Center for Quantum Technology (WACQT) No. 2017.0449)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid371226en
dc.identifier.citationBengtsson, A., Hill, D., Li, M., Di, M., Cinthio, M., Erlöv, T., Andersson-Engels, S., Reistad, N., Walther, A., Rippe, L. and Kröll, S. (2019) 'Characterization and modeling of acousto-optic signal strengths in highly scattering media', Biomedical Optics Express, 10(11), 371226, pp. 5565-5584. DOI: 10.1364/BOE.10.005565en
dc.identifier.doi10.1364/BOE.10.005565en
dc.identifier.eissn2156-7085
dc.identifier.endpage5584en
dc.identifier.issued11en
dc.identifier.journaltitleBiomedical Optics Expressen
dc.identifier.startpage5565en
dc.identifier.urihttps://hdl.handle.net/10468/8869
dc.identifier.volume10en
dc.language.isoenen
dc.publisherOptical Society of Americaen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/en
dc.relation.urihttps://www.osapublishing.org/boe/fulltext.cfm?uri=boe-10-11-5565&id=422082
dc.rights©2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreementen
dc.rights.urihttps://doi.org/10.1364/OA_License_v1en
dc.subjectInhomogeneously broadened lasersen
dc.subjectMedical imagingen
dc.subjectOptical pumpingen
dc.subjectReal time imagingen
dc.subjectSlow lighten
dc.subjectTissue imagingen
dc.titleCharacterization and modeling of acousto-optic signal strengths in highly scattering mediaen
dc.typeArticle (peer-reviewed)en
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