Endothelial dysfunction does not occur after acute, elevated homocysteine exposure of the lumen of the iliac artery of the anaesthetised pig

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dc.check.date2025-10-09en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorMarkos, Farouken
dc.contributor.authorO’Leary, Andrew J.en
dc.contributor.authorNoble, Mark I. M.en
dc.contributor.authorRuane-O’Hora, Thereseen
dc.date.accessioned2025-01-13T14:36:28Z
dc.date.available2025-01-13T14:36:28Z
dc.date.issued2024-10-09en
dc.description.abstractElevated luminal homocysteine has been linked with cardiovascular disease; however, whether there is a direct effect of homocysteine on blood vessel endothelium is not clear. In this study, the acute effect of luminal homocysteine on iliac artery endothelial function was assessed in the anaesthetised pig. Methods: Hyperhomocysteinaemic blood was injected into an occluded segment of the iliac in the anaesthetised pig for 20 min, and the effect on atrial diameter during the occlusion and during the reactive hyperaemia assessed. Results: No significant changes in arterial diameter or pressure were observed during the incubation period at homocysteine concentrations of 10, 20, 40 and 100 µ<sc>M</sc>. There was also no difference in the magnitude of the iliac diameter increase in the response to reactive hyperaemia when the incubation period was completed. Conclusion: There is no evidence of endothelial dysfunction in response to an acute 20-min elevation in homocysteine in an intact conduit artery.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMarkos, F., O’Leary, A. J., Noble, M. I. M. and Ruane-O’Hora, T. (2024) Endothelial dysfunction does not occur after acute, elevated homocysteine exposure of the lumen of the iliac artery of the anaesthetised pig', Journal of Vascular Research, 61(6), pp. 298–303. https://doi.org/10.1159/000541398en
dc.identifier.doi10.1159/000541398en
dc.identifier.eissn1423-0135en
dc.identifier.endpage303en
dc.identifier.issn1018-1172en
dc.identifier.issued6en
dc.identifier.journaltitleJournal of Vascular Researchen
dc.identifier.startpage298en
dc.identifier.urihttps://hdl.handle.net/10468/16806
dc.identifier.volume61en
dc.language.isoenen
dc.publisherKargeren
dc.relation.ispartofJournal of Vascular Researchen
dc.rights© 2024, S. Karger AG, Basel. All rights reserved.en
dc.subjectHomocysteineen
dc.subjectEndotheliumen
dc.subjectVascular diseaseen
dc.subjectShear stressen
dc.titleEndothelial dysfunction does not occur after acute, elevated homocysteine exposure of the lumen of the iliac artery of the anaesthetised pigen
dc.typeArticle (peer-reviewed)en
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