Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American, and Australian cohorts

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dc.check.date2020-02-20
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorSantos, S.
dc.contributor.authorVoerman, E.
dc.contributor.authorAmiano, P.
dc.contributor.authorBarros, H.
dc.contributor.authorBeilin, L. J.
dc.contributor.authorBergström, A.
dc.contributor.authorCharles, M-A.
dc.contributor.authorChatzi, L.
dc.contributor.authorChevrier, C.
dc.contributor.authorChrousos, G. P.
dc.contributor.authorCorpeleijn, E.
dc.contributor.authorCosta, O.
dc.contributor.authorCostet, N.
dc.contributor.authorCrozier, S.
dc.contributor.authorDevereux, G.
dc.contributor.authorDoyon, M.
dc.contributor.authorEggesbø, M.
dc.contributor.authorFantini, M. P.
dc.contributor.authorFarchi, S.
dc.contributor.authorForastiere, F.
dc.contributor.authorGeorgiu, V.
dc.contributor.authorGodfrey, K. M.
dc.contributor.authorGori, D.
dc.contributor.authorGrote, V.
dc.contributor.authorHanke, W.
dc.contributor.authorHertz-Picciotto, I.
dc.contributor.authorHeude, B.
dc.contributor.authorHivert, M-F.
dc.contributor.authorHryhorczuk, D.
dc.contributor.authorHuang, R-C.
dc.contributor.authorInskip, H.
dc.contributor.authorKarvonen, A. M.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorKoletzko, B.
dc.contributor.authorKüpers, L. K.
dc.contributor.authorLagström, H.
dc.contributor.authorLehmann, I.
dc.contributor.authorMagnus, P.
dc.contributor.authorMajewska, R.
dc.contributor.authorMäkelä, J.
dc.contributor.authorManios, Y.
dc.contributor.authorMcAuliffe, F. M.
dc.contributor.authorMcDonald, S. W.
dc.contributor.authorMehegan, J.
dc.contributor.authorMelén, E.
dc.contributor.authorMommers, M.
dc.contributor.authorMorgen, C. S.
dc.contributor.authorMoschonis, G.
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorNí Chaoimh, Carol E.
dc.contributor.authorNohr, E. A.
dc.contributor.authorNybo Andersen, A-M.
dc.contributor.authorOken, E.
dc.contributor.authorOostvogels, A. J. J. M.
dc.contributor.authorPac, A.
dc.contributor.authorPapadopoulou, E.
dc.contributor.authorPekkanen, J.
dc.contributor.authorPizzi, C.
dc.contributor.authorPolanska, K.
dc.contributor.authorPorta, D.
dc.contributor.authorRichiardi, L.
dc.contributor.authorRifas-Shiman, S. L.
dc.contributor.authorRoeleveld, N.
dc.contributor.authorRonfani, L.
dc.contributor.authorSantos, A. C.
dc.contributor.authorStandl, M.
dc.contributor.authorStigum, H.
dc.contributor.authorStoltenberg, C.
dc.contributor.authorThiering, E.
dc.contributor.authorThijs, C.
dc.contributor.authorTorrent, M.
dc.contributor.authorTough, S. C.
dc.contributor.authorTrnovec, T.
dc.contributor.authorTurner, S.
dc.contributor.authorvan Gelder, M. M. H. J.
dc.contributor.authorvan Rossem, L.
dc.contributor.authorvon Berg, A.
dc.contributor.authorVrijheid, M.
dc.contributor.authorVrijkotte, T. G. M.
dc.contributor.authorWest, J.
dc.contributor.authorWijga, A. H.
dc.contributor.authorWright, J.
dc.contributor.authorZvinchuk, O.
dc.contributor.authorSørensen, T. I. A.
dc.contributor.authorLawlor, D. A.
dc.contributor.authorGaillard, R.
dc.contributor.authorJaddoe, V. W. V.
dc.contributor.funderNational Children’s Research Centre, Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderFood Standards Agencyen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-04-17T09:19:00Z
dc.date.available2019-04-17T09:19:00Z
dc.date.issued2019-02-20
dc.date.updated2019-04-17T09:00:35Z
dc.description.abstractObjective: To assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design: Individual participant data meta‐analysis of 39 cohorts. Setting: Europe, North America, and Oceania. Population: 265 270 births. Methods: Information on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures: Gestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results: Higher maternal pre‐pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions: Maternal pre‐pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre‐pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.en
dc.description.sponsorshipNational Children’s Research Centre, Ireland (Cork BASELINE Birth Cohort Study); Health Research Board (SCOPE Ireland funded by the Health Research Board, Ireland (CSA 2007/2)); Food Standards Agency, United Kingdom (grant no. TO7060)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSantos, S. et al. (2019) 'Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American, and Australian cohorts', BJOG: An International Journal of Obstetrics & Gynaecology, In Press, doi: 10.1111/1471-0528.15661en
dc.identifier.doi10.1111/1471-0528.15661en
dc.identifier.endpage16en
dc.identifier.issn1470-0328
dc.identifier.journaltitleBJOG : an international journal of obstetrics and gynaecologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7773
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/1471-0528.15661
dc.rights© 2019 Royal College of Obstetricians and Gynaecologists. This is the peer reviewed version of the following article: ‘Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta‐analysis of European, North American, and Australian cohorts’, BJOG 2019, which has been published in final form at https://doi.org/10.1111/1471-0528.15661 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archivingen
dc.subjectBirthweighten
dc.subjectBody mass indexen
dc.subjectPregnancy complicationsen
dc.subjectPreterm birth weight gainen
dc.titleImpact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American, and Australian cohortsen
dc.typeArticle (peer-reviewed)en
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