Activation of a TLR9 mediated innate immune response in preeclampsia

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dc.contributor.authorWilliamson, Rachel D.
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorMcCarthy, Cathal M.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2019-11-19T12:08:20Z
dc.date.available2019-11-19T12:08:20Z
dc.date.issued2019-04-11
dc.description.abstractPreeclampsia is a multisystemic disorder leading to the development of a placental ischemic microenvironment with a resultant increase in oxidative stress. There is evidence that mitochondrial dysfunction and the innate immune system both play a role in the pathophysiology of this disease. Mitochondrial DAMPs such as mtDNA bind specific pattern recognition receptors such as Toll-like receptor 9 (TLR9) on the endosomal surface of immune cells, in particular neutrophils, subsequently activating them and triggering an innate response. We hypothesised that the exaggerated innate immune response seen in preeclampsia is provoked by dysfunctional mitochondria. Here we provide evidence that TLR9 activity is significantly increased at time of disease in women with preeclampsia. Furthermore, we show activation of neutrophil markers, Calprotectin, Myeloperoxidase (MPO), and IL-8 are significantly increased at time of disease compared to uncomplicated pregnancies. This research supports a potential role of TLR9 activation of an innate immune response evident in preeclampsia which may possibly be initially triggered by dysfunctional mitochondria.en
dc.description.sponsorshipHRA-POR-2015-1240en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid5920en
dc.identifier.citationWilliamson, R.D., McCarthy, F.P., Kenny, L.C. and McCarthy, C.M., 2019. Activation of a TLR9 mediated innate immune response in preeclampsia. Scientific reports, 9(1), (5920). DOI:10.1038/s41598-019-42551-wen
dc.identifier.doi10.1038/s41598-019-42551-wen
dc.identifier.eissn2045-2322
dc.identifier.endpage8en
dc.identifier.issued1en
dc.identifier.journaltitleScientific Reportsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9086
dc.identifier.volume9en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://www.nature.com/articles/s41598-019-42551-w
dc.rights© The Author(s) 2019en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPreeclampsiaen
dc.subjectTLR9en
dc.subjectImmune responseen
dc.subject~Pharmacology and Therapeutics - Journal Articles~en
dc.titleActivation of a TLR9 mediated innate immune response in preeclampsiaen
dc.typeArticle (peer-reviewed)en
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