Improvements in clinical outcomes in children with cystic fibrosis aged six and 16 years

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dc.contributor.authorFinn, Bryan P.
dc.contributor.authorMillar, Sean R.
dc.contributor.authorCronin, K.
dc.contributor.authorCrowley, J.
dc.contributor.authorDunne, S.
dc.contributor.authorJennings, R.
dc.contributor.authorKeating, E.
dc.contributor.authorMurphy, C.
dc.contributor.authorO'Donovan, D.
dc.contributor.authorShanahan, P.
dc.contributor.authorShort, C.
dc.contributor.authorMullane, D.
dc.contributor.authorNí Chroinin, M.
dc.date.accessioned2020-12-14T09:19:36Z
dc.date.available2020-12-14T09:19:36Z
dc.date.issued2020
dc.description.abstractAims: Our aim was to assess if outcomes for cystic fibrosis (CF) patients at six & sixteen years of age have improved in the last 17 years looking at FEV1, BMI and death. Methods: A retrospective observational study using a prospectively maintained database of CF patients at Cork University Hospital. Results: 84 patients were included in the 16-year-old data and 89 patients were included in the six-year-old data. The mean FEV1 and BMI (16 years) for the 2002-2007 group was 72.9±21.0% and 18.9±2.53 respectively, 2008-2013 group was 75.4±27.2% and 19.8±2.7 and for the 2014-2018 group was 95.2±16.0% and 22.9±4.1. The percentage of patients (16 years) with chronic pseudomonas status was 37.9% (11/30) in the 2002-2007 group, 51.6 % (16/31) in the 2008-2013 group and 4.2% (1/24) in the 2014-2018 group. The relationship between FEV1 and FVC with BMI remained significant in multivariate analysis (P <0.001). The mean FEV1 (six years) for the 2002-2007 group was 90.7±16.1%, 2008-2013 group was 99.3±17.9% and for the 2014-2018 group was 100.9±15.8%. Conclusions: Improvements in FEV1 and BMI aged six and 16 years are notable as well as a significant decline in the number of patients with chronic pseudomonas.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidP119en
dc.identifier.citationFinn, B. P., Millar, S. R., Cronin, K., Crowley, J., Dunne, S., Jennings, R., Keating, E., Murphy, C., O’Donovan, D., Shanahan, P. and Short, C. (2020) 'Improvements in clinical outcomes in children with cystic fibrosis aged six and 16 years', Irish Medical Journal, 113 (7), P119 (6pp). Available at: https://www.imj.ie/wp-content/uploads/2020/07/Improvements-in-Clinical-Outcomes-in-Children-with-Cystic-Fibrosis-aged-Six-and-16-years.pdf (Accessed: 14 December 2020)en
dc.identifier.endpage6en
dc.identifier.issn0332-3102
dc.identifier.issued7en
dc.identifier.journaltitleIrish Medical Journalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/10833
dc.identifier.volume113en
dc.language.isoenen
dc.publisherIrish Medical Organisationen
dc.relation.urihttps://imj.ie/irish-medical-journal-july-august-2020-vol-113-no-7/
dc.rights© 2020, Irish Medical Organisation. All rights reserved.en
dc.subjectPseudomonasen
dc.subjectCystic fibrosisen
dc.subjectCFen
dc.subjectFEV1en
dc.subjectBMIen
dc.titleImprovements in clinical outcomes in children with cystic fibrosis aged six and 16 yearsen
dc.typeArticle (peer-reviewed)en
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