Hydroxylamine-O-sulfonic acid as a new reducing agent for the formation of nearly monodisperse gold nanoparticles in water: synthesis, characterisation and bioconjugation

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dc.contributor.authorRahme, Kamil
dc.contributor.authorHolmes, Justin D.
dc.date.accessioned2016-05-24T14:13:58Z
dc.date.available2016-05-24T14:13:58Z
dc.date.issued2014-06
dc.date.updated2015-01-07T12:38:16Z
dc.description.abstractGold nanoparticles (Au NPs) with diameters ranging between 15 and 150 nm have been synthesised in water. 15 and 30 nm Au NPs were obtained by the Turkevich and Frens method using sodium citrate as both a reducing and stabilising agent at high temperature (Au NPs-citrate), while 60, 90 and 150 nm Au NPs were formed using hydroxylamine-o-sulfonic acid (HOS) as a reducing agent for HAuCl4 at room temperature. This new method using HOS is an extension of the approaches previously reported for producing Au NPs with mean diameters above 40 nm by direct reduction. Functionalised polyethylene glycol-based thiol polymers were used to stabilise the pre-synthesised Au NPs. The nanoparticles obtained were characterised using uv-visible spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). Further bioconjugation on 15, 30 and 90 nm PEGylated Au NPs were performed by grafting Bovine Serum Albumin, Transferrin and Apolipoprotein E (ApoE).en
dc.description.statusPeer revieweden
dc.description.urihttp://www.techconnectworld.com/Nanotech2014/en
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRahme, K. and Holmes, J. D. (2014) ‘Hydroxylamine-O-sulfonic acid as a new reducing agent for the formation of nearly monodisperse gold nanoparticles in water: synthesis, characterisation and Bioconjugation.’ Nanotech: advanced materials and applications. 15-18 June Washington DC, USA. In Nanotechology 2014, vol 1, pp 147-150. ISBN 978-1-4822-5826-4.en
dc.identifier.endpage150en
dc.identifier.isbn978-1-4822-5826-4
dc.identifier.journaltitleNanotechology 2014en
dc.identifier.startpage147en
dc.identifier.urihttps://hdl.handle.net/10468/2611
dc.identifier.volume1en
dc.language.isoenen
dc.relation.ispartofNSTI-Nanotech
dc.relation.urihttp://www.nsti.org/procs/Nanotech2014v1
dc.rights© 2014 Nano Science and Technology Institute.en
dc.subjectGold nanoparticlesen
dc.subjectHydroxylamine-O-sulfonic aciden
dc.subjectPolyethylene glycolen
dc.subjectProteinen
dc.subjectBioconjucationen
dc.titleHydroxylamine-O-sulfonic acid as a new reducing agent for the formation of nearly monodisperse gold nanoparticles in water: synthesis, characterisation and bioconjugationen
dc.typeConference itemen
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