Influence of minor β-CN genotypes on coagulation properties and proteolytic pathways of bovine milk

Simple item page
dc.contributor.authorGai, Nanen
dc.contributor.authorUniacke-Lowe, Thereseen
dc.contributor.authorGoulding, David A.en
dc.contributor.authorO'Regan, Jonathanen
dc.contributor.authorAffolter, Michaelen
dc.contributor.authorKelly, Alan L.en
dc.contributor.funderSociété des Produits Nestléen
dc.contributor.funderTeagasc Food Research Centreen
dc.date.accessioned2025-07-22T10:59:35Z
dc.date.available2025-07-22T10:59:35Z
dc.date.issued2025-07-14en
dc.description.abstractNumerous studies have examined the effects of the two most common β-casein (β-CN) genetic variants, A1 and A2, on the physicochemical and functional properties of bovine milk. However, relatively minor variants of this protein such as B and I remain under-researched. This study collected milk with four β-CN genotypes, A1B, A2B, A1I, and A2I, across three collection occasions to investigate their functional and proteolytic properties. Milk of the B variant exhibited similar behaviour to A1 regarding rennet and acid coagulation properties, while I was similar to A2. Furthermore, the Glu121-Arg122 and Arg122-Gln123 bonds in the β-CN B variant were more sensitive to plasmin-derived proteolysis than Ser122 in other variants, leading to more peptides from cleavage at Arg122-related sites. These findings support grouping genotypes based on the amino acid (AA) at position 67, as variants sharing the same AA at this position exhibit similar processability, while also highlighting the significant impact of AA at position 122 for proteolysis in milk or dairy products.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid106352en
dc.identifier.citationGai, N., Uniacke-Lowe, T., Goulding, D. A., O'Regan, J., Affolter, M. and Kelly, A. L. (2025) 'Influence of minor β-CN genotypes on coagulation properties and proteolytic pathways of bovine milk', International Dairy Journal, 169, 106352 (8pp). https://doi.org/10.1016/j.idairyj.2025.106352en
dc.identifier.doi10.1016/j.idairyj.2025.106352en
dc.identifier.endpage8en
dc.identifier.issn9586946en
dc.identifier.journaltitleInternational Dairy Journalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/17738
dc.identifier.volume169
dc.language.isoenen
dc.publisherElsevier Ltden
dc.rights© 2025, the Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAspartameen
dc.subjectMammalsen
dc.subjectPhysicochemical propertiesen
dc.subjectProteolysisen
dc.subjectAmino-acidsen
dc.subjectBovine milken
dc.subjectCoagulation propertiesen
dc.subjectFunctional propertiesen
dc.subjectFunctionalsen
dc.subjectGenetic variantsen
dc.subjectPhysicochemical propertyen
dc.subjectProcessabilityen
dc.subjectPropertyen
dc.subjectCoagulationen
dc.subject~Food and Nutritional Sciences - Journal Articles~en
dc.titleInfluence of minor β-CN genotypes on coagulation properties and proteolytic pathways of bovine milken
dc.typeArticle (peer reviewed)en
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
1-s2.0-S0958694625001712-main.pdf
Size:
2.64 MB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Thumbnail Image
Name:
1-s2.0-S0958694625001712-mmc1.docx
Size:
21.65 KB
Format:
Microsoft Word XML
Description:
Supplementary Data
Download
Collections
School of Food and Nutritional Sciences