A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

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dc.contributor.authorIvanov, Ivaylo P.
dc.contributor.authorAtkins, John F.
dc.contributor.authorMichael, Antony J.
dc.contributor.funderBiotechnology and Biological Sciences Research Council
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderNational Institutes of Health
dc.date.accessioned2017-11-14T13:24:31Z
dc.date.available2017-11-14T13:24:31Z
dc.date.issued2010
dc.description.abstractIn many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.en
dc.description.sponsorshipNational Institute of Health (R01 GM079523); Biotechnology and Biological Sciences Research Council (Institute Development Fellowship (BB/E024467/1)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationIvanov, I. P., Atkins, J. F. and Michael, A. J. (2010) 'A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation', Nucleic Acids Research, 38(2), pp. 353-359. doi: 10.1093/nar/gkp1037en
dc.identifier.doi10.1093/nar/gkp1037
dc.identifier.endpage359
dc.identifier.issn0305-1048
dc.identifier.issued2
dc.identifier.journaltitleNucleic Acids Researchen
dc.identifier.startpage353
dc.identifier.urihttps://hdl.handle.net/10468/5028
dc.identifier.volume38
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urihttps://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkp1037
dc.rights© 2009, the Authors. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.5/uk/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5/uk/
dc.subjectS-adenosylmethionine decarboxylaseen
dc.subjectOrnithine decarboxylaseen
dc.subjectMessenger RNAen
dc.subjectAntizymeen
dc.subjectExpressionen
dc.subjectBindingen
dc.subjectProteinen
dc.subjectTerminationen
dc.subjectElongationen
dc.subjectInitiationen
dc.titleA profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulationen
dc.typeArticle (peer-reviewed)en
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