Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

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Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

Hayes, John A.; Eccles, Kevin S.; Lawrence, Simon E.; Moynihan, Humphrey A.
Date: 2012
Copyright: Copyright © 2012, Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Carbohydrate Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Research [349, 15 February 2012, 108–112] http://dx.doi.org/10.1016/j.carres.2011.12.018
Related: http://www.sciencedirect.com/science/article/pii/S0008621511006136
Citation: John A. Hayes, Kevin S. Eccles, Simon E. Lawrence, Humphrey A. Moynihan (2012) 'Preparation and characterisation of solid state forms of paracetamol-O-glucuronide'. Carbohydrate Research, 349 :108-112. http://dx.doi.org/10.1016/j.carres.2011.12.018
Published Version: 10.1016/j.carres.2011.12.018

Abstract:

The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.

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