Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

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dc.contributor.authorHayes, John A.
dc.contributor.authorEccles, Kevin S.
dc.contributor.authorLawrence, Simon E.
dc.contributor.authorMoynihan, Humphrey A.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2013-03-07T11:24:01Z
dc.date.available2013-03-07T11:24:01Z
dc.date.issued2012
dc.date.updated2013-03-06T17:54:51Z
dc.description.abstractThe synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.en
dc.description.sponsorshipScience Foundation Ireland (07/SRC/B1158); Science Foundation Ireland (05/PICA/B802/EC07)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJohn A. Hayes, Kevin S. Eccles, Simon E. Lawrence, Humphrey A. Moynihan (2012) 'Preparation and characterisation of solid state forms of paracetamol-O-glucuronide'. Carbohydrate Research, 349 :108-112. http://dx.doi.org/10.1016/j.carres.2011.12.018en
dc.identifier.doi10.1016/j.carres.2011.12.018
dc.identifier.endpage112en
dc.identifier.issn0008-6215
dc.identifier.journaltitleCarbohydrate Researchen
dc.identifier.startpage108en
dc.identifier.urihttps://hdl.handle.net/10468/1018
dc.identifier.volume349en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0008621511006136
dc.rightsCopyright © 2012, Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Carbohydrate Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Research [349, 15 February 2012, 108–112] http://dx.doi.org/10.1016/j.carres.2011.12.018en
dc.subjectParacetamol-O-glucuronideen
dc.subjectSolvatesen
dc.subjectHydratesen
dc.subjectX-ray diffractionen
dc.titlePreparation and characterisation of solid state forms of paracetamol-O-glucuronideen
dc.typeArticle (peer-reviewed)en
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