Preparation and characterisation of solid state forms of paracetamol-O-glucuronide
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Accepted Version
Date
2012
Authors
Hayes, John A.
Eccles, Kevin S.
Lawrence, Simon E.
Moynihan, Humphrey A.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Published Version
Abstract
The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.
Description
Keywords
Paracetamol-O-glucuronide , Solvates , Hydrates , X-ray diffraction
Citation
John A. Hayes, Kevin S. Eccles, Simon E. Lawrence, Humphrey A. Moynihan (2012) 'Preparation and characterisation of solid state forms of paracetamol-O-glucuronide'. Carbohydrate Research, 349 :108-112. http://dx.doi.org/10.1016/j.carres.2011.12.018