Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

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Date
2012
Authors
Hayes, John A.
Eccles, Kevin S.
Lawrence, Simon E.
Moynihan, Humphrey A.
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Elsevier
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Abstract
The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.
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Keywords
Paracetamol-O-glucuronide , Solvates , Hydrates , X-ray diffraction
Citation
John A. Hayes, Kevin S. Eccles, Simon E. Lawrence, Humphrey A. Moynihan (2012) 'Preparation and characterisation of solid state forms of paracetamol-O-glucuronide'. Carbohydrate Research, 349 :108-112. http://dx.doi.org/10.1016/j.carres.2011.12.018