The incidence of first seizures, epilepsy and seizure mimics in a geographically defined area.

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dc.contributor.author Maloney, Eimer M.
dc.contributor.author Chaila, Elijah
dc.contributor.author O'Reilly, Éilis J.
dc.contributor.author Costello, Daniel J.
dc.date.accessioned 2020-07-14T12:01:55Z
dc.date.available 2020-07-14T12:01:55Z
dc.date.issued 2020-06-09
dc.identifier.citation Maloney, E. M., Chaila, E., O'Reilly, É. J. and Costello, D. J. (2020) 'The incidence of first seizures, epilepsy and seizure mimics in a geographically defined area', Neurology. doi: 10.1212/WNL.0000000000009980 en
dc.identifier.issn 0028-3878
dc.identifier.uri http://hdl.handle.net/10468/10253
dc.identifier.doi 10.1212/WNL.0000000000009980 en
dc.description.abstract To determine the incidence of first seizures, epilepsy and seizure mimics in a geographically defined area using the updated 2014 International League Against Epilepsy (ILAE) definition which allows an epilepsy diagnosis following a single seizure where risk of further seizures over the next 10 years is approximately 60% or more. This replaced the 1993 definition where epilepsy was diagnosed when a person had two or more seizures separated by 24 hours. Using multiple overlapping methods of case ascertainment followed by individual case classification by an epileptologist we identified all first seizures, new diagnosis of epilepsy, and seizure mimics occurring in a defined geographical area (population 542,868) 01/01/2017-12/31/2017. Incidence was age-standardised to the Standard European Population. We compared incidence rates when using the 2014 and 1993 ILAE definitions. When applying the 2014 ILAE definition of epilepsy the incidence of new diagnosis of epilepsy was 62 per 100,000 (age-standardised 74), compared to 41 per 100,000 (age-standardised 48) when applying the 1993 definition, and the difference was more pronounced at older ages. The incidence of all first seizures and of seizure mimics was 102 per 100,000 (age-standardised 123) and 94 per 100,000 (age-standardised 111), respectively. The most frequently encountered seizure mimic was syncope. Application of the 2014 ILAE definition of epilepsy resulted in higher incidence of new diagnosis of epilepsy compared to the 1993 definition. The incidence of seizure mimics almost equals that of all first seizures. Seizures, epilepsy and seizure mimics represent a significant burden to healthcare systems. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Academy of Neurology en
dc.rights © 2020, American Academy of Neurology. All rights reserved. en
dc.subject First seizures en
dc.subject Epilepsy en
dc.subject International League Against Epilepsy ILAE en
dc.subject 2014 en
dc.subject Definition en
dc.subject Seizure mimics en
dc.title The incidence of first seizures, epilepsy and seizure mimics in a geographically defined area. en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Daniel Costello, Medicine, University College Cork, Cork, Ireland. +353-21-490-3000 Email: daniel.costello@hse.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-06-09
dc.date.updated 2020-07-14T11:34:05Z
dc.description.version Published Version en
dc.internal.rssid 525042468
dc.internal.pmid 32518150
dc.description.status Peer reviewed en
dc.identifier.journaltitle Neurology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress daniel.costello@hse.ie en
dc.internal.bibliocheck In press. Add vol / issue / page range. Amend citation as necessary. Upload PV from PubMed Central after 12 month embargo on 09 June 2021 and replace AV. en
dc.identifier.eissn 1526-632X


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