The role of the gut microbiome in the development of schizophrenia

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dc.contributor.author Kelly, John R.
dc.contributor.author Minuto, Chiara
dc.contributor.author Cryan, John F.
dc.contributor.author Clarke, Gerard
dc.contributor.author Dinan, Timothy G.
dc.date.accessioned 2020-07-30T12:44:54Z
dc.date.available 2020-07-30T12:44:54Z
dc.date.issued 2020-04-23
dc.identifier.citation Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G. and Dinan, T. G. (2020) 'The role of the gut microbiome in the development of schizophrenia', Schizophrenia Research, doi: 10.1016/j.schres.2020.02.010 en
dc.identifier.issn 0920-9964
dc.identifier.uri http://hdl.handle.net/10468/10340
dc.identifier.doi 10.1016/j.schres.2020.02.010 en
dc.description.abstract Schizophrenia is a heterogeneous neurodevelopmental disorder involving the convergence of a complex and dynamic bidirectional interaction of genetic expression and the accumulation of prenatal and postnatal environmental risk factors. The development of the neural circuitry underlying social, cognitive and emotional domains requires precise regulation from molecular signalling pathways, especially during critical periods or “windows”, when the brain is particularly sensitive to the influence of environmental input signalling. Many of the brain regions involved, and the molecular substrates sub-serving these domains are responsive to life-long microbiota-gut-brain (MGB) axis signalling. This intricate microbial signalling system communicates with the brain via the vagus nerve, immune system, enteric nervous system, enteroendocrine signalling and production of microbial metabolites, such as short-chain fatty acids. Preclinical data has demonstrated that MGB axis signalling influences neurotransmission, neurogenesis, myelination, dendrite formation and blood brain barrier development, and modulates cognitive function and behaviour patterns, such as, social interaction, stress management and locomotor activity. Furthermore, preliminary clinical studies suggest altered gut microbiota profiles in schizophrenia. Unravelling MGB axis signalling in the context of an evolving dimensional framework in schizophrenia may provide a more complete understanding of the neurobiological architecture of this complex condition and offers the possibility of translational interventions. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S0920996420300864
dc.rights © 2020 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Schizophrenia en
dc.subject Psychosis en
dc.subject Microbiota en
dc.subject Microbiome en
dc.subject Gut-brain axis en
dc.subject Psychobiotics en
dc.title The role of the gut microbiome in the development of schizophrenia en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ted Dinan, Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.dinan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-04-23
dc.date.updated 2020-07-30T12:35:00Z
dc.description.version Accepted Version en
dc.internal.rssid 528344834
dc.description.status Peer reviewed en
dc.identifier.journaltitle Schizophrenia Research en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.internal.IRISemailaddress j.cryan@ucc.ie en
dc.internal.IRISemailaddress g.clarke@ucc.ie en
dc.internal.bibliocheck In Press, update citation, add volume, page numbers


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© 2020 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2020 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.
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