Exploiting the continuous in situ generation of mesyl azide for use in a telescoped process

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dc.contributor.author O'Mahony, Rosella M.
dc.contributor.author Lynch, Denis
dc.contributor.author Hayes, Hannah L. D.
dc.contributor.author Ní Thuama, Eilís
dc.contributor.author Donnellan, Philip
dc.contributor.author Jones, Roderick C.
dc.contributor.author Glennon, Brian
dc.contributor.author Collins, Stuart G.
dc.contributor.author Maguire, Anita R.
dc.date.accessioned 2020-11-18T11:01:59Z
dc.date.available 2020-11-18T11:01:59Z
dc.date.issued 2017-08-21
dc.identifier.citation O'Mahony, R. M., Lynch, D., Hayes, H. L. D., Ní Thuama, E., Donnellan, P., Jones, R. C., Glennon, B., Collins, S. G. and Maguire, A. R. (2017) 'Exploiting the Continuous in situ Generation of Mesyl Azide for Use in a Telescoped Process', European Journal of Organic Chemistry, 2017(44), pp. 6533-6539. doi: 10.1002/ejoc.201700871 en
dc.identifier.issued 44 en
dc.identifier.startpage 6533 en
dc.identifier.endpage 6539 en
dc.identifier.issn 1434-193X
dc.identifier.uri http://hdl.handle.net/10468/10769
dc.identifier.doi 10.1002/ejoc.201700871 en
dc.description.abstract The hazardous diazo transfer reagent mesyl azide has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to β‐keto esters and a β‐ketosulfone was successful. In‐line phase separation, by means of a continuous liquid–liquid separator enabled direct telescoping with a thermal Wolff rearrangement. 12 en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201700871
dc.rights © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: O'Mahony, R.M. et al. (2017), Exploiting the Continuous in situ Generation of Mesyl Azide for Use in a Telescoped Process. Eur. J. Org. Chem., 2017, which has been published in final form at https://doi.org/10.1002/ejoc.201700871 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Continuous flow en
dc.subject Diazo compounds en
dc.subject Flow en
dc.subject Chemistry en
dc.subject Synthetic methods en
dc.title Exploiting the continuous in situ generation of mesyl azide for use in a telescoped process en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Anita Maguire, Vice President For Research, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.maguire@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2020-11-18T10:52:21Z
dc.description.version Accepted Version en
dc.internal.rssid 419942753
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle European Journal of Organic Chemistry en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.maguire@ucc.ie en
dc.internal.IRISemailaddress denis.lynch@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Infrastructure Programme/15/RI/3221/IE/Process Flow Spectroscopy (ProSpect); Advanced Reaction Understanding using Flow Nuclear Magnetic Resonance (NMR) and Infrared (IR) Spectroscopies, with On-Line Ultra-Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS)/ en


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