Improvements in clinical outcomes in children with cystic fibrosis aged six and 16 years
Finn, Bryan P.; Millar, Sean R.; Cronin, K.; Crowley, J.; Dunne, S.; Jennings, R.; Keating, E.; Murphy, C.; O'Donovan, D.; Shanahan, P.; Short, C.; Mullane, D.; Ní Chroinin, M.
Date:
2020
Copyright:
© 2020, Irish Medical Organisation. All rights reserved.
Citation:
Finn, B. P., Millar, S. R., Cronin, K., Crowley, J., Dunne, S., Jennings, R., Keating, E., Murphy, C., O’Donovan, D., Shanahan, P. and Short, C. (2020) 'Improvements in clinical outcomes in children with cystic fibrosis aged six and 16 years', Irish Medical Journal, 113 (7), P119 (6pp). Available at: https://www.imj.ie/wp-content/uploads/2020/07/Improvements-in-Clinical-Outcomes-in-Children-with-Cystic-Fibrosis-aged-Six-and-16-years.pdf (Accessed: 14 December 2020)
Abstract:
Aims: Our aim was to assess if outcomes for cystic fibrosis (CF) patients at six & sixteen years of age have improved in the last 17 years looking at FEV1, BMI and death. Methods: A retrospective observational study using a prospectively maintained database of CF patients at Cork University Hospital. Results: 84 patients were included in the 16-year-old data and 89 patients were included in the six-year-old data. The mean FEV1 and BMI (16 years) for the 2002-2007 group was 72.9±21.0% and 18.9±2.53 respectively, 2008-2013 group was 75.4±27.2% and 19.8±2.7 and for the 2014-2018 group was 95.2±16.0% and 22.9±4.1. The percentage of patients (16 years) with chronic pseudomonas status was 37.9% (11/30) in the 2002-2007 group, 51.6 % (16/31) in the 2008-2013 group and 4.2% (1/24) in the 2014-2018 group. The relationship between FEV1 and FVC with BMI remained significant in multivariate analysis (P <0.001). The mean FEV1 (six years) for the 2002-2007 group was 90.7±16.1%, 2008-2013 group was 99.3±17.9% and for the 2014-2018 group was 100.9±15.8%. Conclusions: Improvements in FEV1 and BMI aged six and 16 years are notable as well as a significant decline in the number of patients with chronic pseudomonas.
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