Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1beta and IL-8 gene expression

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dc.contributor.author Beecher, Christine
dc.contributor.author Daly, Mairead
dc.contributor.author Berry, Donagh P.
dc.contributor.author Klostermann, Katja
dc.contributor.author Flynn, James
dc.contributor.author Meaney, William
dc.contributor.author Hill, Colin
dc.contributor.author McCarthy, Tommie V.
dc.contributor.author Ross, R. Paul
dc.contributor.author Giblin, Linda
dc.date.accessioned 2013-04-29T14:58:21Z
dc.date.available 2013-04-29T14:58:21Z
dc.date.copyright 2009
dc.date.issued 2009-02
dc.identifier.citation Beecher C, Daly M, Berry DP, Klostermann K, Flynn J, Meaney W, Hill C, McCarthy TV, Ross RP, Giblin L. (2009) Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1beta and IL-8 gene expression. Journal of Dairy Research, 76(3):340-8. doi: 10.1017/S0022029909004154 en
dc.identifier.volume 76 en
dc.identifier.issued 3 en
dc.identifier.startpage 340 en
dc.identifier.endpage 348 en
dc.identifier.uri http://hdl.handle.net/10468/1099
dc.identifier.doi 10.1017/S0022029909004154
dc.description.abstract Mastitis is one of the most costly diseases to the dairy farming industry. Conventional antibiotic therapy is often unsatisfactory for successful treatment of mastitis and alternative treatments are continually under investigation. We have previously demonstrated, in two separate field trials, that a probiotic culture, Lactococcus lactis DPC 3147, was comparable to antibiotic therapy to treat bovine mastitis. To understand the mode of action of this therapeutic, we looked at the detailed immune response of the host to delivery of this live strain directly into the mammary gland of six healthy dairy cows. All animals elicited signs of udder inflammation 7 h post infusion. At this time, clots were visible in the milk of all animals in the investigation. The most pronounced increase in immune gene expression was observed in Interleukin (IL)-1β and IL-8, with highest expression corresponding to peaks in somatic cell count. Infusion with a live culture of a Lc. lactis leads to a rapid and considerable innate immune response. en
dc.description.sponsorship Science Foundation Ireland (SFI-CSET); Teagasc (Walsh Fellowship); Teagasc (Teagasc Retooling Programme under the National Development Plan) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Cambridge University Press en
dc.relation.uri http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6015060&fulltextType=RA&fileId=S0022029909004154
dc.rights © Proprietors of Journal of Dairy Research 2009 en
dc.subject Mastitis en
dc.subject Lactococcus lactis en
dc.subject Probiotic treatment en
dc.subject.lcsh Microbiology. en
dc.title Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1beta and IL-8 gene expression en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://publish.ucc.ie/researchprofiles/D010/chill en
dc.internal.authorcontactother Colin Hill, Alimentary Pharmabiotic Centre, University College Cork, Cork. E-mail: c.hill@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.rssid 121848250
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Teagasc en
dc.contributor.funder Dairy Research Trust, Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Dairy Research en
dc.internal.IRISemailaddress c.hill@ucc.ie en


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