Body mass index trajectories in the first 5 years and associated antenatal factors
Murray, Deirdre M.
Hawkes, Colin P.
Kiely, Mairead E.
Ní Chaoimh, Carol
McCarthy, Fergus P.
Frontiers Media S.A.
Background: The increasing prevalence of childhood obesity is an important public health issue and the development of obesity in early life and associated risk factors need to be better understood. The aim of this study was to identify distinct body mass index trajectories in the first 5 years of life and to examine their associations with factors identified in pregnancy, including metabolic parameters. Methods: BMI measurements from 2,172 children in Ireland enrolled in the BASELINE cohort study with BMI assessments at birth, 2, 6, and 12 months, and 2 and 5 years were analyzed. Growth mixture modeling was used to identify distinct BMI trajectories, and multivariate multinomial logistic regression was used to assess the association between these trajectories and antenatal factors. Results: Three distinct BMI trajectories were identified: normal (89.6%); rapid gain in the first 6 months (7.8%); and rapid BMI after 12 months (2.6%). Male sex and higher maternal age increased the likelihood of belonging to the rapid gain in the first 6 months trajectory. Raised maternal BMI at 15 weeks of pregnancy and lower cord blood IGF-2 were associated with rapid gain after 1 year. Conclusion: Sex, maternal age and BMI, and IGF-2 levels were found to be associated with BMI trajectories in early childhood departing from normal growth. Further research and extended follow-up to examine the effects of childhood growth patterns are required to understand their relationship with health outcomes.
Growth , Childhood obesity , Epidemiology , Growth mixture modeling , IGF
Mattsson, M., Murray, D. M., Hawkes, C. P.; Kiely, M., Ní Chaoimh, C., McCarthy, F. P., Biesma, R. and Boland, F. (2021) 'Body mass index trajectories in the first 5 years and associated antenatal factors', Frontiers in Pediatrics, 9, 622381 (9pp). doi: 10.3389/fped.2021.622381
© 2021, Mattsson, Murray, Hawkes, Kiely, Ní Chaoimh, McCarthy, Biesma and Boland. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.