Ethanolamine: A potential promoiety with additional effects in the brain [Mini review]

Show simple item record Gwanyanya, Asfree Godsmark, Christie Nicole Kelly-Laubscher, Roisin 2022-08-05T11:08:39Z 2022-08-05T11:08:39Z 2020-12-11
dc.identifier.citation Gwanyanya, A., Godsmark, C. N. and Kelly-Laubscher, R. (2022) 'Ethanolamine: A Potential Promoiety with Additional Effects in the Brain. [Mini review]', CNS & Neurological Disorders Drug Targets, 21 (2), pp. 108-117. doi: 10.2174/1871527319999201211204645 en
dc.identifier.volume 21 en
dc.identifier.issued 2 en
dc.identifier.startpage 108 en
dc.identifier.endpage 117 en
dc.identifier.issn 1996-3181
dc.identifier.doi 10.2174/1871527319999201211204645 en
dc.description.abstract Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological ac-tions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer's disease. This mini-review focuses on the effects of ethanolamine in the CNS and highlights the possible implications of these effects for drug design. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Bentham Science en
dc.rights This is the accepted version of an article published in CNS & Neurological Disorders - Drug Targets. The published manuscript is available at EurekaSelect via en
dc.subject Ethanolamine en
dc.subject Brain en
dc.subject CNS en
dc.subject Phospholipids en
dc.subject Prodrug en
dc.subject Synaptic en
dc.subject Neuromodulator en
dc.title Ethanolamine: A potential promoiety with additional effects in the brain [Mini review] en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Roisin Kelly, Pharmacology & Therapeutics, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en 2022-08-05T11:00:21Z
dc.description.version Accepted Version en
dc.internal.rssid 550974706
dc.internal.pmid 33319663
dc.description.status Peer reviewed en
dc.identifier.journaltitle CNS & neurological disorders drug targets en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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