Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection

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dc.contributor.author Mathieson, Sean R.
dc.contributor.author Livingstone, Vicki
dc.contributor.author Low, Evonne
dc.contributor.author Pressler, Ronit
dc.contributor.author Rennie, Janet M.
dc.contributor.author Boylan, Geraldine B.
dc.date.accessioned 2016-10-24T11:31:17Z
dc.date.available 2016-10-24T11:31:17Z
dc.date.issued 2016-07-25
dc.identifier.citation Mathieson, S. R., Livingstone, V., Low, E., Pressler, R., Rennie, J. M. and Boylan, G. B. (2016) ‘Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection,’ Clinical Neurophysiology, 127(10), pp. 3343-3350. doi: 10.1016/j.clinph.2016.07.007 en
dc.identifier.volume 127 en
dc.identifier.issued 10 en
dc.identifier.startpage 3343 en
dc.identifier.endpage 3350 en
dc.identifier.issn 1388-2457
dc.identifier.issn 1872-8952
dc.identifier.uri http://hdl.handle.net/10468/3210
dc.identifier.doi 10.1016/j.clinph.2016.07.007
dc.description.abstract Objective: Phenobarbital increases electroclinical uncoupling and our preliminary observations suggest it may also affect electrographic seizure morphology. This may alter the performance of a novel seizure detection algorithm (SDA) developed by our group. The objectives of this study were to compare the morphology of seizures before and after phenobarbital administration in neonates and to determine the effect of any changes on automated seizure detection rates. Methods: The EEGs of 18 term neonates with seizures both pre- and post-phenobarbital (524 seizures) administration were studied. Ten features of seizures were manually quantified and summary measures for each neonate were statistically compared between pre- and post-phenobarbital seizures. SDA seizure detection rates were also compared. Results: Post-phenobarbital seizures showed significantly lower amplitude (p < 0.001) and involved fewer EEG channels at the peak of seizure (p < 0.05). No other features or SDA detection rates showed a statistical difference. Conclusion: These findings show that phenobarbital reduces both the amplitude and propagation of seizures which may help to explain electroclinical uncoupling of seizures. The seizure detection rate of the algorithm was unaffected by these changes. Significance: The results suggest that users should not need to adjust the SDA sensitivity threshold after phenobarbital administration. en
dc.description.sponsorship Wellcome Trust (Strategic Translational Award (098983)); Science Foundation Ireland (SFI Principal Investigator (10/IN.1/B3036) and Research Centre Awards (12/RC/2272) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Automated seizure detection en
dc.subject Electroclinical uncoupling en
dc.subject Neonatal seizures en
dc.title Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Geraldine Boylan, Department of Paediatrics and Child Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.boylan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Wellcome Trust en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Clinical Neurophysiology en
dc.internal.copyrightchecked !!CORA!! en
dc.internal.IRISemailaddress g.boylan@ucc.ie en


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© 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Except where otherwise noted, this item's license is described as © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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