Mesenchymal stromal cells (MSCs) and colorectal cancer - a troublesome twosome for the anti-tumour immune response?

Show simple item record O'Malley, Grace Heijltjes, Madelon Houston, Aileen M. Rani, Sweta Ritter, Thomas Egan, Laurence J. Ryan, Aideen E. 2016-11-02T16:07:10Z 2016-11-02T16:07:10Z 2016-08
dc.identifier.citation O'Malley, Grace; Heijltjes, Madelon; Houston, Aileen M.; Rani, Sweta; Ritter, Thomas; Egan, Laurence J.; Ryan, Aideen E. (2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer - a troublesome twosome for the anti-tumour immune response?'. Oncotarget, 7 (37):60752-60774. doi: 10.18632/oncotarget.11354 en
dc.identifier.volume 7 en
dc.identifier.issued 37 en
dc.identifier.startpage 60752 en
dc.identifier.endpage 60774 en
dc.identifier.issn 1949-2553
dc.identifier.doi 10.18632/oncotarget.11354
dc.description.abstract The tumour microenvironment (TME) is an important factor in determining the growth and metastasis of colorectal cancer, and can aid tumours by both establishing an immunosuppressive milieu, allowing the tumour avoid immune clearance, and by hampering the efficacy of various therapeutic regimens. The tumour microenvironment is composed of many cell types including tumour, stromal, endothelial and immune cell populations. It is widely accepted that cells present in the TME acquire distinct functional phenotypes that promote tumorigenesis. One such cell type is the mesenchymal stromal cell (MSC). Evidence suggests that MSCs exert effects in the colorectal tumour microenvironment including the promotion of angiogenesis, invasion and metastasis. MSCs immunomodulatory capacity may represent another largely unexplored central feature of MSCs tumour promoting capacity. There is considerable evidence to suggest that MSCs and their secreted factors can influence the innate and adaptive immune responses. MSC-immune cell interactions can skew the proliferation and functional activity of T-cells, dendritic cells, natural killer cells and macrophages, which could favour tumour growth and enable tumours to evade immune cell clearance. A better understanding of the interactions between the malignant cancer cell and stromal components of the TME is key to the development of more specific and efficacious therapies for colorectal cancer. Here, we review and explore MSC- mediated mechanisms of suppressing anti-tumour immune responses in the colon tumour microenvironment. Elucidation of the precise mechanism of immunomodulation exerted by tumour-educated MSCs is critical to inhibiting immunosuppression and immune evasion established by the TME, thus providing an opportunity for targeted and efficacious immunotherapy for colorectal cancer growth and metastasis. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Impact Journals en
dc.rights Copyright @ 2016 Impact Journals, LLC en
dc.rights.uri en
dc.subject Mesenchymal stromal cells en
dc.subject Tumour microenvironment en
dc.subject Colorectal cancer en
dc.subject Immunosuppression en
dc.subject Immunomodulation en
dc.title Mesenchymal stromal cells (MSCs) and colorectal cancer - a troublesome twosome for the anti-tumour immune response? en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Aileen Houston, Medicine Department , University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en 2016-11-02T16:01:18Z
dc.description.version Published Version en
dc.internal.rssid 370304726
dc.internal.pmid 27542276
dc.description.status Peer reviewed en
dc.identifier.journaltitle Oncotarget en
dc.internal.copyrightchecked No en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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Copyright @ 2016 Impact Journals, LLC Except where otherwise noted, this item's license is described as Copyright @ 2016 Impact Journals, LLC
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