From belly to brain: targeting the ghrelin receptor in appetite and food intake regulation
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Published Version
Date
2017-01-27
Authors
Howick, Kenneth P.
Griffin, Brendan T.
Cryan, John F.
Schellekens, Harriët
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Published Version
Abstract
Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and subsequent food intake. The ghrelinergic system has therefore received considerable attention as a therapeutic target to reduce appetite in obesity as well as to stimulate food intake in conditions of anorexia, malnutrition and cachexia. As the therapeutic potential of targeting this hormone becomes clearer, it is apparent that its pleiotropic actions span both the central nervous system and peripheral organs. Despite a wealth of research, a therapeutic compound specifically targeting the ghrelin system for appetite modulation remains elusive although some promising effects on metabolic function are emerging. This is due to many factors, ranging from the complexity of the ghrelin receptor (Growth Hormone Secretagogue Receptor, GHSR-1a) internalisation and heterodimerization, to biased ligand interactions and compensatory neuroendocrine outputs. Not least is the ubiquitous expression of the GHSR-1a, which makes it impossible to modulate centrallymediated appetite regulation without encroaching on the various peripheral functions attributable to ghrelin. It is becoming clear that ghrelin’s central signalling is critical for its effects on appetite, body weight regulation and incentive salience of food. Improving the ability of ghrelin ligands to penetrate the blood brain barrier would enhance central delivery to GHSR-1a expressing brain regions, particularly within the mesolimbic reward circuitry.
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Keywords
Ghrelin , Desacyl-ghrelin , Appetite , GHSR-1a , Obesity , Cachexia , Food reward , Mesolimbic reward circuitry , Blood brain barrier
Citation
Howick, K., Griffin, B., Cryan, J. and Schellekens, H. (2017) 'From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation', International Journal of Molecular Sciences, 18(2), 273. doi:10.3390/ijms18020273