Biocidal inactivation of Lactococcus lactis bacteriophages: efficacy and targets of commonly used sanitizers
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Published Version
Date
2017-02-02
Authors
Hayes, Stephen
Murphy, James
Mahony, Jennifer
Lugli, Gabriele A.
Ventura, Marco
Noben, Jean-Paul
Franz, Charles M. A. P.
Neve, Horst
Nauta, Arjen
van Sinderen, Douwe
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media
Published Version
Abstract
Lactococcus lactis strains, being intensely used in the dairy industry, are particularly vulnerable to members of the so-called 936 group of phages. Sanitization and disinfection using purpose-made biocidal solutions is a critical step in controlling phage contamination in such dairy processing plants. The susceptibility of 36 936 group phages to biocidal treatments was examined using 14 biocides and commercially available sanitizers. The targets of a number of these biocides were investigated by means of electron microscopic and proteomic analyses. The results from this study highlight significant variations in phage resistance to biocides among 936 phages. Furthermore, rather than possessing resistance to specific biocides or biocide types, biocide-resistant phages tend to possess a broad tolerance to multiple classes of antimicrobial compounds.
Description
Keywords
Phage , Fermentation , Starter culture , Dairy , Resistance , Chemical
Citation
Hayes, S., Murphy, J., Mahony, J., Lugli, G. A., Ventura, M., Noben, J.-P., Franz, C. M. A. P., Neve, H., Nauta, A. and van Sinderen, D. (2017) ‘Biocidal inactivation of Lactococcus lactis bacteriophages: efficacy and targets of commonly used sanitizers’, Frontiers in Microbiology, 8, 107 ((14 pp). doi: 10.3389/fmicb.2017.00107