Biocidal inactivation of Lactococcus lactis bacteriophages: efficacy and targets of commonly used sanitizers

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dc.contributor.author Hayes, Stephen
dc.contributor.author Murphy, James
dc.contributor.author Mahony, Jennifer
dc.contributor.author Lugli, Gabriele A.
dc.contributor.author Ventura, Marco
dc.contributor.author Noben, Jean-Paul
dc.contributor.author Franz, Charles M. A. P.
dc.contributor.author Neve, Horst
dc.contributor.author Nauta, Arjen
dc.contributor.author van Sinderen, Douwe
dc.date.accessioned 2017-03-03T10:02:40Z
dc.date.available 2017-03-03T10:02:40Z
dc.date.issued 2017-02-02
dc.identifier.citation Hayes, S., Murphy, J., Mahony, J., Lugli, G. A., Ventura, M., Noben, J.-P., Franz, C. M. A. P., Neve, H., Nauta, A. and van Sinderen, D. (2017) ‘Biocidal inactivation of Lactococcus lactis bacteriophages: efficacy and targets of commonly used sanitizers’, Frontiers in Microbiology, 8, 107 ((14 pp). doi: 10.3389/fmicb.2017.00107 en
dc.identifier.volume 8 en
dc.identifier.startpage 1 en
dc.identifier.endpage 14 en
dc.identifier.issn 1664-302X
dc.identifier.uri http://hdl.handle.net/10468/3736
dc.identifier.doi 10.3389/fmicb.2017.00107
dc.description.abstract Lactococcus lactis strains, being intensely used in the dairy industry, are particularly vulnerable to members of the so-called 936 group of phages. Sanitization and disinfection using purpose-made biocidal solutions is a critical step in controlling phage contamination in such dairy processing plants. The susceptibility of 36 936 group phages to biocidal treatments was examined using 14 biocides and commercially available sanitizers. The targets of a number of these biocides were investigated by means of electron microscopic and proteomic analyses. The results from this study highlight significant variations in phage resistance to biocides among 936 phages. Furthermore, rather than possessing resistance to specific biocides or biocide types, biocide-resistant phages tend to possess a broad tolerance to multiple classes of antimicrobial compounds. en
dc.description.sponsorship Science Foundation Ireland (SFI Investigator Award Ref. No. 13/IA/1953; ); Irish Research Council (Enterprise Partnership Scheme Postgraduate Scholarship; Technology Innovation Development Award Ref. No. 14/TIDA/2287; Starting Investigator Research Grant Ref. No. 15/SIRG/3430); Universiteit Antwerpen (Hercules Foundation Project R-3986: LC–MS@UHasselt: Linear Trap Quadrupool-Orbitrap mass spectrometer.) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.relation.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288689/
dc.rights © 2017, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Phage en
dc.subject Fermentation en
dc.subject Starter culture en
dc.subject Dairy en
dc.subject Resistance en
dc.subject Chemical en
dc.title Biocidal inactivation of Lactococcus lactis bacteriophages: efficacy and targets of commonly used sanitizers en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Douwe van Sinderen, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: d.vansinderen@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-03-03T09:42:34Z
dc.description.version Published Version en
dc.internal.rssid 385708905
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Research Council en
dc.contributor.funder Universiteit Antwerpen en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers In Microbiology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress d.vansinderen@ucc.ie en
dc.identifier.articleid 107


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© 2017, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2017, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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