Alterations of haemodynamic parameters in spontaneously hypertensive rats by Aristolochia ringens Vahl. (Aristolochiaceae)

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dc.contributor.author Aigbe, Flora Ruth
dc.contributor.author Munavvar, Abdul Sattar Zubaid
dc.contributor.author Rathore, Hassan
dc.contributor.author Eseyin, Olorunfemi
dc.contributor.author Pei, Yen Pei
dc.contributor.author Akhtar, Safia
dc.contributor.author Chohan, Ashfaq
dc.contributor.author Jin, Hui
dc.contributor.author Khoo, Jooli
dc.contributor.author Tan, Samual
dc.contributor.author Lazhari, Mohammed
dc.contributor.author Afzar, Sheryar
dc.contributor.author Ahmed, Fiaz
dc.contributor.author Adeyemi, Olufunmilayo Olaide
dc.contributor.author Johns, Edward J.
dc.date.accessioned 2017-05-03T10:15:23Z
dc.date.available 2017-05-03T10:15:23Z
dc.date.issued 2017-02
dc.identifier.citation Aigbe, F. R., Munavvar, A. S. Z., Rathore, H., Eseyin, O., Pei, Y. P., Akhtar, S., Chohan, A., Jin, H., Khoo, J., Tan, S., Lazhari, M., Afzar, S., Ahmed, F., Adeyemi, O. O. and Johns, E. J. (2017) 'Alterations of haemodynamic parameters in spontaneously hypertensive rats by Aristolochia ringens Vahl. (Aristolochiaceae)', Journal of Traditional and Complementary Medicine, 8(1), pp. 72-80. doi: 10.1016/j.jtcme.2017.02.006 en
dc.identifier.volume 8
dc.identifier.issued 1
dc.identifier.startpage 72
dc.identifier.endpage 80
dc.identifier.issn 2225-4110
dc.identifier.uri http://hdl.handle.net/10468/3908
dc.identifier.doi 10.1016/j.jtcme.2017.02.006
dc.description.abstract Aristolochia ringens Vahl. (Aristolochiaceae (AR); 馬兜鈴 mǎ dōu líng) is used traditionally in Nigeria for the management of various disorders including oedema. Preliminary investigation revealed its modulatory effect on the cardiovascular system. This study was aimed at investigating the effect of the aqueous root extract of A. ringens (AR) on haemodynamic parameters of spontaneously hypertensive rats (SHRs). The effect of oral subacute (21 days) and intravenous acute exposure of SHRs to the extract were assessed using tail cuff and carotid artery canulation methods respectively. In the latter, the effect of chloroform, butanol and aqueous fractions of AR were also evaluated. The extract significantly reduced systolic and diastolic blood pressures in SHRs, with peak reductions of 20.3% and 26.7% respectively at 50 mg/kg by the 21st day of oral subacute exposure. Upon intravenous exposure, AR (50 mg/kg) reduced systolic and diastolic blood pressure by as much as 53.4 ± 2.2 and 49.2 ± 2.8 mmHg respectively. A dose-dependent reduction in heart rate, significant at 25 and 50 mg/kg was also observed. Hexamethonium (20 mg/kg) and atropine (1 mg/kg) inhibited the extract's reduction of systolic blood pressure, diastolic blood pressure and heart rate significantly. The extract's butanol fraction produced the greatest systolic and diastolic blood pressures reduction of 67.0 ± 3.8 and 68.4 mmHg respectively at 25 mg/kg and heart rate reduction of 40 ± 7 beats per minute at 50 mg/kg. HPLC analysis revealed the presence of 4-hydroxybenzoic acid and quercetin in AR. The extract's alterations of haemodynamic parameters in this study show that it has hypotensive effect on spontaneously hypertensive rats. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd on behalf of the Center for Food and Biomolecules, National Taiwan University en
dc.rights © 2017 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license. en
dc.rights.uri http://creativecommons.org/ licenses/by-nc-nd/4.0/ en
dc.subject Aristolochia ringens en
dc.subject Aqueous extract en
dc.subject Spontaneously hypertensive rats en
dc.subject Phenolics en
dc.subject Butanol fraction en
dc.title Alterations of haemodynamic parameters in spontaneously hypertensive rats by Aristolochia ringens Vahl. (Aristolochiaceae) en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Edward James Johns, Physiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: e.j.johns@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-05-03T09:17:29Z
dc.description.version Published Version en
dc.internal.rssid 393598343
dc.contributor.funder University of Lagos, Nigeria
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Traditional and Complementary Medicine en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress e.j.johns@ucc.ie en
dc.relation.project University of Lagos, Nigeria (Doctoral Research Grant) en


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© 2017 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license. Except where otherwise noted, this item's license is described as © 2017 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.
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