The application of molecular tethers in controlling axial chirality

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Date
2016-06
Authors
Reen, Michael
O'Sullivan, Timothy P.
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Publisher
Bentham Science Publishers
Published Version
10.2174/1570193X13666160510114626
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Abstract
Atropisomeric biaryl compounds are an attractive target in organic chemistry due to their abundance in nature and their utility as ligands in catalysis. Among the methods available for their synthesis, the use of chiral tethers offers very high levels of stereocontrol. In this article, we review the application of molecular tethers in controlling axial chirality across a range of different ligands and natural products.
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Keywords
Atropisomeric biaryl compound , Axial chirality , Biaryls , Stereoinduction , Synthesis
Citation
Reen, M. and O'Sullivan, Timothy P. (2016) 'The Application of Molecular Tethers in Controlling Axial Chirality'. Mini-Reviews in Organic Chemistry, 13(3), pp. 206-218. doi: 10.2174/1570193X13666160510114626
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URI
https://hdl.handle.net/10468/4119
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Chemistry - Journal Articles
Analytical & Biological Chemistry Research Facility - Journal Articles
Pharmacy - Journal Articles
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© 2016 Bentham Science Publishers