Clinical use of cerebral oximetry in extremely preterm infants is feasible

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dc.contributor.author Hyttel-Sorensen, Simon
dc.contributor.author Austin, Topun
dc.contributor.author van Bel, Frank
dc.contributor.author Benders, Manon
dc.contributor.author Claris, Olivier
dc.contributor.author Dempsey, Eugene M.
dc.contributor.author Fumagalli, Monica
dc.contributor.author Gluud, Christian
dc.contributor.author Hagmann, Cornelia
dc.contributor.author Hellström-Westas, Lena
dc.contributor.author Lemmers, Petra
dc.contributor.author Naulaers, Gunnar
dc.contributor.author van Oeveren, Wim
dc.contributor.author Pellicer, Adelina
dc.contributor.author Pichler, Gerhard
dc.contributor.author Roll, Claudia
dc.contributor.author Stoy, Lina Saem
dc.contributor.author Wolf, Martin
dc.contributor.author Greisen, Gorm
dc.date.accessioned 2017-09-01T15:00:39Z
dc.date.available 2017-09-01T15:00:39Z
dc.date.issued 2013-01
dc.identifier.citation Hyttel-Sorensen, S. et al (2013) 'Clinical use of cerebral oximetry in extremely preterm infants is feasible', Danish Medical Journal, 60 (1): A4533 (5 pp.) en
dc.identifier.volume 60 en
dc.identifier.issued 1 en
dc.identifier.startpage A4533-1 en
dc.identifier.endpage A4533-5 en
dc.identifier.issn 2245-1919
dc.identifier.uri http://hdl.handle.net/10468/4608
dc.description.abstract Introduction: The research programme Safeguarding the Brains of our smallest Children (SafeBoosC) aims to test the benefits and harms of cerebral near-infrared spectroscopy (NIRS) oximetry in infants born before 28 weeks of gestation. In a phase II trial, infants will be randomised to visible cerebral NIRS oximetry with pre-specified treatment guidelines compared to standard care with blinded NIRS-monitoring. The primary outcome is duration multiplied with the extent outside the normal range of regional tissue oxygen saturation of haemoglobin (rStO2) of 55 to 85% in percentage hours (burden). This study was a pilot of the Visible ­Oximetry Group. Material and methods: This was an observational study including ten infants. Results: The median gestational age was 26 weeks + three days, and the median start-up time was 133 minutes after delivery. The median recording time was 69.7 hours, mean rStO2 was 64.2 ± 4.5%, median burden of hyper- and hy­poxia was 30.3% hours (range 2.8-112.3). Clinical staff responded to an out of range value 29 times – only once to values above 85%. In comparison, there were 83 periods of more than ten minutes with an rStO2 below 55% and four episodes with an rStO2 above 85%. These periods accounted for 72% of the total hypoxia burden. A total of 18 of the 29 interventions were adjustments of FiO2 which in 13 of the 18 times resulted in an out-of-range SpO2. Two infants suffered second-degree burns from the sensor. Five infants died. In all cases, this was unrelated to NIRS monitoring and treatment. Conclusion: The intervention of early cerebral NIRS monitoring proved feasible, but prolonged periods of hypoxia went untreated. Thus, a revision of the treatment guideline and an alarm system is required. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher The Danish Medical Association
dc.relation.uri http://www.danmedj.dk/portal/page/portal/danmedj.dk/dmj_forside/PAST_ISSUE/2013/DMJ_2013_01/A4533
dc.rights © 2013, The Authors; Published by The Danish Medical Association, distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. en
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/ en
dc.subject Near infrared spectroscopy en
dc.subject Oxygen saturation en
dc.subject Premature Infants en
dc.subject Hypoxia en
dc.subject SafeBoosC en
dc.subject Cerebral NIRS oximetry en
dc.title Clinical use of cerebral oximetry in extremely preterm infants is feasible en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Eugene Dempsey, Paediatrics & Child Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.dempsey@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-09-01T14:50:19Z
dc.description.version Published Version en
dc.internal.rssid 348786842
dc.internal.wokid WOS:000341962200006
dc.contributor.funder Elsass Fonden en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Danish Medical Journal en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.dempsey@ucc.ie en
dc.identifier.articleid A4533


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© 2013, The Authors; Published by The Danish Medical Association, distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Except where otherwise noted, this item's license is described as © 2013, The Authors; Published by The Danish Medical Association, distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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