Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review

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dc.contributor.author Blackshields, Caroline A.
dc.contributor.author Crean, Abina M.
dc.date.accessioned 2017-09-06T08:36:43Z
dc.date.available 2017-09-06T08:36:43Z
dc.date.issued 2017-06-17
dc.identifier.citation Blackshields, C. A. and Crean, A. M. (2017) 'Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review', Pharmaceutical Development and Technology. doi:10.1080/10837450.2017.1339197 en
dc.identifier.issn 1083-7450
dc.identifier.issn 1097-9867
dc.identifier.uri http://hdl.handle.net/10468/4633
dc.identifier.doi 10.1080/10837450.2017.1339197
dc.description.abstract There has been a noticeable shift from pharmaceutical batch processing towards a more continuous mode of manufacture for solid oral dosage forms. Continuous solid oral dose processes would not be possible in the absence of a highly accurate feeding system. The performance of feeders defines the content of formulations and is therefore a critical operation in continuous manufacturing of solid dosage forms. It was the purpose of this review to review the role of the initial powder feeding step in a continuous manufacturing process. Different feeding mechanisms are discussed with a particular emphasis on screw controlled loss in weight (LIW) feeding. The importance of understanding the physical properties of the raw materials and its impact on the feeding process is reviewed. Prior knowledge of materials provides an initial indication of how the powders will behave through processing and facilitates in the selection of the most suitable (i) feeder (capacity), (ii) feeding mechanism, and (iii) in the case of screw feeder - screw type. The studies identified in this review focus on the impact of material on powder feeding performance. en
dc.description.sponsorship Enterprise Ireland / IDA Ireland (Pharmaceutical Manufacturing Technology Centre Grant: TC 2013-0015) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Taylor & Francis Group en
dc.rights © 2017, Informa UK Limited, trading as Taylor & Francis Group. This is an Accepted Manuscript of an article published by Taylor & Francis in Pharmaceutical Development and Technology on 2017.06.17, available online: http://www.tandfonline.com/10.1080/10837450.2017.1339197 en
dc.subject Continuous manufacturing en
dc.subject Loss-in-weight feeding en
dc.subject Pharmaceutical powder properties en
dc.title Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Abina Crean, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.crean@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2018-06-17
dc.date.updated 2017-09-05T11:44:54Z
dc.description.version Accepted Version en
dc.internal.rssid 400723625
dc.contributor.funder Enterprise Ireland en
dc.contributor.funder IDA Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Pharmaceutical Development and Technology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.crean@ucc.ie en
dc.internal.bibliocheck Check for vol. / issue / page range. Amend citation if necessary.


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