Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus

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dc.contributor.author Kozareva, Danka A.
dc.contributor.author O'Leary, Olivia F.
dc.contributor.author Cryan, John F.
dc.contributor.author Nolan, Yvonne M.
dc.date.accessioned 2017-10-09T11:30:36Z
dc.date.available 2017-10-09T11:30:36Z
dc.date.issued 2017-10-03
dc.identifier.citation Kozareva, D. A., O'Leary, O. F., Cryan, J. F. and Nolan, Y. M. 'Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus', Hippocampus, In Press. doi: 10.1002/hipo.22805 en
dc.identifier.startpage 1 en
dc.identifier.endpage 27 en
dc.identifier.issn 1098-1063
dc.identifier.uri http://hdl.handle.net/10468/4846
dc.identifier.doi 10.1002/hipo.22805
dc.description.abstract Adolescence is a sensitive period of neurodevelopment during which life experiences and the surrounding environment can have profound effects on the brain. Neurogenesis is a neurodevelopmental process of generating functional neurons from neural stem cells. Hippocampal neurogenesis occurs throughout the lifespan and has been shown to play a role in learning, memory and in mood regulation. In adulthood it is influenced by extrinsic environmental factors such as exercise and stress. Intrinsic factors that regulate hippocampal neurogenesis include the orphan nuclear receptor TLX (Nr2e1) which is primarily expressed in the neurogenic niches of the brain. While mechanisms regulating adult hippocampal neurogenesis have been widely studied, less is known on how hippocampal neurogenesis is affected during adolescence. Thus, the aim of this study was to investigate the influence of both TLX and isolation stress on exercise-induced increases in neurogenesis in running and sedentary conditions during adolescence. Single- (i.e. isolation stress) wild type and Nr2e1-/- or pair-housed wild type mice were housed in sedentary conditions or allowed free access to running wheels for 3 weeks during the adolescent period. A reduction of neuronal survival was evident in mice lacking TLX, and exercise did not increase hippocampal neurogenesis in these Nr2e1-/- mice. This suggests that TLX is necessary for the pro-neurogenic effects of exercise during adolescence. Interestingly, although social isolation during adolescence did not affect hippocampal neurogenesis, it prevented an exercise-induced increase in neurogenesis in the ventral hippocampus. Together these data demonstrate the importance of intrinsic and extrinsic factors in promoting an exercise-induced increase in neurogenesis at this key point in life. This article is protected by copyright. All rights reserved. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.rights © 2017 John Wiley & Sons, Inc.This is the peer reviewed version of the following article: Kozareva, D. A., O'Leary, O. F., Cryan, J. F. and Nolan, Y. M., Deletion of Tlx and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus. Hippocampus. Accepted Author Manuscript. which has been published in final form at http://dx.doi.org/10.1002/hipo.22805. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Adult neurogenesis en
dc.subject Adolescence en
dc.subject Stress en
dc.subject Exercise en
dc.subject TLX en
dc.title Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Yvonne Nolan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: y.nolan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted for 12 months after publication by request of the publisher. en
dc.check.date 2018-10-03
dc.date.updated 2017-10-09T11:21:17Z
dc.description.version Accepted Version en
dc.internal.rssid 414213945
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Hippocampus en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress y.nolan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IA/1537/IE/The nuclear receptor TLX as a cell intrinsic regulator underlying inflammation and stress-induced changes in hippocampal neurogenesis: relevance to cognitive disorders/ en


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