A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

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Date
2010
Authors
Ivanov, Ivaylo P.
Atkins, John F.
Michael, Antony J.
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Publisher
Oxford University Press
Published Version
10.1093/nar/gkp1037
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Abstract
In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.
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Keywords
S-adenosylmethionine decarboxylase , Ornithine decarboxylase , Messenger RNA , Antizyme , Expression , Binding , Protein , Termination , Elongation , Initiation
Citation
Ivanov, I. P., Atkins, J. F. and Michael, A. J. (2010) 'A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation', Nucleic Acids Research, 38(2), pp. 353-359. doi: 10.1093/nar/gkp1037
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https://hdl.handle.net/10468/5028
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Biochemistry and Cell Biology - Journal Articles
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© 2009, the Authors. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.5/uk/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.