Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance

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dc.contributor.author Pajic, Natasa Z. Bubic
dc.contributor.author Todosijevic, Marija N.
dc.contributor.author Vuleta, Gordana M.
dc.contributor.author Cekic, Nebojsa D.
dc.contributor.author Dobricic, Vladimir D.
dc.contributor.author Vucen, Sonja R.
dc.contributor.author Calija, Bojan R.
dc.contributor.author Lukic, Milica Z.
dc.contributor.author Ilic, Tanja M.
dc.contributor.author Savic, Snezana D.
dc.date.accessioned 2018-02-20T13:24:11Z
dc.date.available 2018-02-20T13:24:11Z
dc.date.issued 2017
dc.identifier.citation Pajić Nataša, Z. B., Todosijević Marija, N., Vuleta Gordana, M., Cekić Nebojša, D., Dobričić Vladimir, D., Vučen Sonja, R., Čalija Bojan, R., Lukić Milica, Ž., Ilić Tanja, M. and Savić Snežana, D. (2017). 'Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance', Acta Pharmaceutica, 67(4), pp. 415–439. doi: 10.1515/acph-2017-0036 en
dc.identifier.volume 67
dc.identifier.issued 4
dc.identifier.startpage 415
dc.identifier.endpage 439
dc.identifier.issn 1330-0075
dc.identifier.uri http://hdl.handle.net/10468/5493
dc.identifier.doi 10.1515/acph-2017-0036
dc.description.abstract Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs. en
dc.description.sponsorship Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (Project TR34031) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher De Gruyter Open en
dc.relation.uri https://www.degruyter.com/view/j/acph.2017.67.issue-4/acph-2017-0036/acph-2017-0036.xml
dc.rights © 2018, the Authors. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0 en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Phase behavior en
dc.subject Delivery en
dc.subject Formulation en
dc.subject Parameters en
dc.subject Transport en
dc.subject Systems en
dc.subject Acid en
dc.title Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Sonja Vucen, Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: svucen@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.wokid WOS:000416603800007
dc.contributor.funder Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
dc.description.status Peer reviewed en
dc.identifier.journaltitle Acta Pharmaceutica en
dc.internal.IRISemailaddress svucen@ucc.ie en


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© 2018, the Authors. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0 Except where otherwise noted, this item's license is described as © 2018, the Authors. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0
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