The effect of berry-based food interventions on markers of cardiovascular and metabolic health: A systematic review of randomized controlled trials

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dc.contributor.author Heneghan, Clara
dc.contributor.author Kiely, Mairead E.
dc.contributor.author Lyons, Jacqueline
dc.contributor.author Lucey, Alice J.
dc.date.accessioned 2018-02-23T15:18:53Z
dc.date.available 2018-02-23T15:18:53Z
dc.date.issued 2018-01-10
dc.identifier.citation Heneghan, C., Kiely, M., Lyons, J. and Lucey, A. (2018) 'The Effect of Berry-Based Food Interventions on Markers of Cardiovascular and Metabolic Health: A Systematic Review of Randomized Controlled Trials', Molecular Nutrition & Food Research, 62(1), 1700645 (12pp). doi: 10.1002/mnfr.201700645 en
dc.identifier.volume 62 en
dc.identifier.issued 1 en
dc.identifier.startpage 1700645-1 en
dc.identifier.endpage 1700645-12 en
dc.identifier.issn 1613-4133
dc.identifier.uri http://hdl.handle.net/10468/5543
dc.identifier.doi 10.1002/mnfr.201700645
dc.description.abstract Scope: Epidemiological evidence, animal, and in vitro studies suggest that berry consumption may ameliorate markers of cardiovascular disease (CVD). The aim of this systematic review is to evaluate findings from berry-based randomized controlled trials (RCTs) to establish the effects of berry consumption on markers of cardiovascular and metabolic health. Methods and results: PubMed and Web of Science are searched for RCTs investigating berry consumption on CVD risk outcomes in adults. A total of 23 studies (which includes 1168 participants) out of 1384 records meet the inclusion criteria. Of these 23 studies, 17 RCTs are of high quality, where 12 RCTs (71%) report beneficial effects of berry consumption on CVD risk markers. Overall, 4/11 RCTs that observe a reduction in systolic and/or diastolic blood pressure (BP); 3/7 RCTs report favorable effects on endothelial function, 2/3 RCTs report improvements in arterial stiffness, 7/17 studies observe benefits in blood lipids, and 3/6 studies report improvements in glycemic profile. Conclusion: Our evaluation of the literature indicates that more than two-thirds of high-quality trials have reported beneficial effects of berry consumption on markers of CVD risk. This systematic review contributes moderate to strong evidence for the inclusion of berries as part of a cardioprotective diet. en
dc.description.sponsorship Department of Agriculture, Food and the Marine (grant 13F539) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.rights © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: C. Heneghan, M. Kiely, J. Lyons, A. Lucey, ‘The Effect of Berry-Based Food Interventions on Markers of Cardiovascular and Metabolic Health: A Systematic Review of Randomized Controlled Trials,’ Mol. Nutr. Food Res. 2018, 62, 1700645, which has been published in final form at http://dx.doi.org/10.1002/mnfr.201700645. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Berries en
dc.subject Cardiovascular risk en
dc.subject Dietary intervention en
dc.subject Randomized controlled trials en
dc.title The effect of berry-based food interventions on markers of cardiovascular and metabolic health: A systematic review of randomized controlled trials en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Alice Lucey, Dept Of Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.lucey@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-01-10
dc.date.updated 2018-02-23T15:03:51Z
dc.description.version Accepted Version en
dc.internal.rssid 427121447
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Molecular Nutrition & Food Research en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress A.Lucey@ucc.ie en


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