The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

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dc.contributor.author Milani, Christian
dc.contributor.author Duranti, Sabrina
dc.contributor.author Bottacini, Francesca
dc.contributor.author Casey, Eoghan
dc.contributor.author Turroni, Francesca
dc.contributor.author Mahony, Jennifer
dc.contributor.author Belzer, Clara
dc.contributor.author Delgado Palacio, Susana
dc.contributor.author Arboleya, Silvia
dc.contributor.author Mancabelli, Leonardo
dc.contributor.author Lugli, Gabriele A.
dc.contributor.author Miguel Rodriguez, Juan
dc.contributor.author Bode, Lars
dc.contributor.author de Vos, Willem M.
dc.contributor.author Gueimonde, Miguel
dc.contributor.author Margolles, Abelardo
dc.contributor.author van Sinderen, Douwe
dc.contributor.author Ventura, Marco
dc.date.accessioned 2018-09-24T12:36:59Z
dc.date.available 2018-09-24T12:36:59Z
dc.date.issued 2017
dc.identifier.citation Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., Lugli, G. A., Rodriguez, J. M., Bode, L., de Vos, W., Gueimonde, M., Margolles, A., van Sinderen, D. and Ventura, M. (2017) 'The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota', Microbiology and Molecular Biology Reviews, 81(4), e00036-17 (67pp). doi: 10.1128/MMBR.00036-17 en
dc.identifier.volume 81
dc.identifier.issued 4
dc.identifier.startpage 1
dc.identifier.endpage 67
dc.identifier.issn 1092-2172
dc.identifier.uri http://hdl.handle.net/10468/6878
dc.identifier.doi 10.1128/MMBR.00036-17
dc.description.abstract The human gut microbiota is engaged in multiple interactions affecting host health during the host's entire life span. Microbes colonize the neonatal gut immediately following birth. The establishment and interactive development of this early gut microbiota are believed to be (at least partially) driven and modulated by specific compounds present in human milk. It has been shown that certain genomes of infant gut commensals, in particular those of bifidobacterial species, are genetically adapted to utilize specific glycans of this human secretory fluid, thus representing a very intriguing example of host-microbe coevolution, where both partners are believed to benefit. In recent years, various metagenomic studies have tried to dissect the composition and functionality of the infant gut microbiome and to explore the distribution across the different ecological niches of the infant gut biogeography of the corresponding microbial consortia, including those corresponding to bacteria and viruses, in healthy and ill subjects. Such analyses have linked certain features of the microbiota/microbiome, such as reduced diversity or aberrant composition, to intestinal illnesses in infants or disease states that are manifested at later stages of life, including asthma, inflammatory bowel disease, and metabolic disorders. Thus, a growing number of studies have reported on how the early human gut microbiota composition/development may affect risk factors related to adult health conditions. This concept has fueled the development of strategies to shape the infant microbiota composition based on various functional food products. In this review, we describe the infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions. Finally, we discuss the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease. en
dc.description.sponsorship Ministerio de Economía y Competitividad (PCIN-2015-233; AGL2016-75476-R); Instituto Danone/Ministerio de Economía y Competitividad (Spanish Plan Estatal de I+D+I (reference AGL2016-78311-R) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Society for Microbiology en
dc.relation.uri https://mmbr.asm.org/content/81/4/e00036-17
dc.rights © 2017, American Society for Microbiology. All rights reserved. en
dc.subject Microbiome en
dc.subject Microbiota en
dc.subject Infants en
dc.subject Metagenomics en
dc.subject Virome en
dc.subject Bifidobacteria en
dc.subject Gut commensals en
dc.subject Probiotics en
dc.subject Gut microbiota en
dc.title The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota en
dc.type Review en
dc.internal.authorcontactother Douwe Van Sinderen, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: d.vansinderen@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland
dc.contributor.funder Instituto Danone
dc.contributor.funder Ministerio de Economía y Competitividad
dc.contributor.funder Ministero dell’Istruzione, dell’Università e della Ricerca
dc.contributor.funder Joint Programming Initiative A healthy diet for a healthy life
dc.description.status Peer reviewed en
dc.identifier.journaltitle Microbiology and Molecular Biology Reviews en
dc.internal.IRISemailaddress d.vansinderen@ucc.ie; marco.ventura@unipr.it en
dc.identifier.articleid e00036-17
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/15/SIRG/3430/IE/Phage-host interactome of the dairy bacterium Streptococcus thermophilus (PHIST)/
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/


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