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Resilience priming: translational models for understanding resiliency and adaptation to early life adversity
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Date
2018-10-11
Authors
Kentner, Amanda C.
Cryan, John F.
Brummelte, Susanne
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Published Version
Abstract
Despite the increasing attention to early life adversity and its long-term consequences on health, behavior, and the etiology of neurodevelopmental disorders, our understanding of the adaptations and interventions that promote resiliency and rescue against such insults are underexplored. Specifically, investigations of the perinatal period often focus on negative events/outcomes. In contrast, positive experiences (i.e. enrichment/parental care//healthy nutrition) favorably influence development of the nervous and endocrine systems. Moreover, some stressors result in adaptations and demonstrations of later-life resiliency. This review explores the underlying mechanisms of neuroplasticity that follow some of these early life experiences and translates them into ideas for interventions in pediatric settings. The emerging role of the gut microbiome in mediating stress susceptibility is also discussed. Since many negative outcomes of early experiences are known, it is time to identify mechanisms and mediators that promote resiliency against them. These range from enrichment, quality parental care, dietary interventions and those that target the gut microbiota.
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Keywords
Early life adversity , Enrichment , Microbiome , Parental care resiliency , Translational research
Citation
Kentner, A. C., Cryan, J. F. and Brummelte, S. (2018) 'Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity', Developmental Psychobiology, In Press, doi: 10.1002/dev.21775
Copyright
© 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Kentner AC, Cryan JF, Brummelte S. Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity. Developmental Psychobiology. 2018; 00:1–26., which has been published in final form at https://doi.org/10.1002/dev.21775. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.