Steroid-induced mental disorders in cancer patients: a systematic review

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Date
2017-11-30
Authors
Ismail, Muhammad Fahmi
Lavelle, Clianna
Cassidy, Eugene M.
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Future Medicine
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Abstract
Corticosteroids are a central part of many cancer treatment regimens. Neuropsychiatric toxicity has complicated their use, including an association with a spectrum of symptoms, from insomnia, cognitive impairment and mood symptoms, to severe mental disorders, including mania, psychosis and severe depression. Although steroid-induced mental disorders were first reported in medicine more than 60 years ago, there is a dearth of evidence available to date on optimal treatment and prevention to guide cancer clinicians. We completed a systematic review of the current evidence for therapeutic and prophylactic interventions of steroid-induced mental disorders in cancer. We searched Medline, Embase and PsycINFO and selected studies related to steroid-induced mental disorder. The studies found were limited to case series and case reports only.
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Keywords
Corticosteroids , Dexamethasone , Glucocorticoids , Hypomania , Mania , Neuropsychiatric adverse effects , Prednisolone , Psychiatric disorder , Psychosissteroid-induced mental disorder
Citation
Ismail, M. F., Lavelle, C. and Cassidy, E. M. (2017) 'Steroid-induced mental disorders in cancer patients: a systematic review', Future Oncology, 13(29), pp. 2719-2731. doi: 10.2217/fon-2017-0306
Copyright
© 2017 Future Medicine. This is the Author’s Accepted Manuscript of a work published in Future Oncology. The version of record is available at https://www.futuremedicine.com/doi/abs/10.2217/fon-2017-0306