Influences on decision-making regarding antipsychotic prescribing in nursing home residents with dementia: a systematic review and synthesis of qualitative evidence

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dc.contributor.author Walsh, Kieran A.
dc.contributor.author Dennehy, Rebecca
dc.contributor.author Sinnott, Carol
dc.contributor.author Browne, John P.
dc.contributor.author Byrne, Stephen
dc.contributor.author McSharry, Jennifer
dc.contributor.author Coughlan, Eoin
dc.contributor.author Timmons, Suzanne
dc.date.accessioned 2018-12-10T15:04:24Z
dc.date.available 2018-12-10T15:04:24Z
dc.date.issued 2017-08-12
dc.identifier.citation Walsh, K. A., Dennehy, R., Sinnott, C., Browne, J., Byrne, S., McSharry, J., Coughlan, E. and Timmons, S. (2017) 'Influences on Decision-Making Regarding Antipsychotic Prescribing in Nursing Home Residents With Dementia: A Systematic Review and Synthesis of Qualitative Evidence', Journal of the American Medical Directors Association, 18(10), pp. 897.e1-897.e12. doi: 10.1016/j.jamda.2017.06.032 en
dc.identifier.volume 18 en
dc.identifier.startpage 897.e1 en
dc.identifier.endpage 897.e12 en
dc.identifier.issn 1525-8610
dc.identifier.uri http://hdl.handle.net/10468/7194
dc.identifier.doi 10.1016/j.jamda.2017.06.032
dc.description.abstract Background: Antipsychotic prescribing is prevalent in nursing homes for the management of behavioral and psychological symptoms of dementia (BPSD), despite the known risks and limited effectiveness. Many studies have attempted to understand this continuing phenomenon, using qualitative research methods, and have generated varied and sometimes conflicting findings. To date, the totality of this qualitative evidence has not been systematically collated and synthesized. Aims: To synthesize the findings from individual qualitative studies on decision-making and prescribing behaviors for antipsychotics in nursing home residents with dementia, with a view to informing intervention development and quality improvement in this field. Methods: A systematic review and synthesis of qualitative evidence was conducted (PROSPERO protocol registration CRD42015029141). Six electronic databases were searched systematically from inception through July 2016 and supplemented by citation, reference, and gray literature searching. Studies were included if they used qualitative methods for both data collection and analysis, and explored antipsychotic prescribing in nursing homes for the purpose of managing BPSD. The Critical Appraisal Skills Program assessment tool was used for quality appraisal. A meta-ethnography was conducted to synthesize included studies. The Confidence in the Evidence from Reviews of Qualitative research approach was used to assess the confidence in individual review findings. All stages were conducted by at least 2 independent reviewers. Results: Of 1534 unique records identified, 18 met the inclusion criteria. Five key concepts emerged as influencing decision-making: organizational capacity; individual professional capability; communication and collaboration; attitudes; regulations and guidelines. A "line of argument" was synthesized and a conceptual model constructed, comparing this decision-making process to a dysfunctional negative feedback loop. Our synthesis indicates that when all stakeholders come together to communicate and collaborate as equal and empowered partners, this can result in a successful reduction in inappropriate antipsychotic prescribing. Conclusions: Antipsychotic prescribing in nursing home residents with dementia occurs in a complex environment involving the interplay of various stakeholders, the nursing home organization, and external influences. To improve the quality of antipsychotic prescribing in this cohort, a more holistic approach to BPSD management is required. Although we have found the issue of antipsychotic prescribing has been extensively explored using qualitative methods, there remains a need for research focusing on how best to change the prescribing behaviors identified. en
dc.description.sponsorship Health Research Board (part of the SPHeRE Programme under Grant No. 33 SPHeRE/2013/1); National Institute for Health Research (clinical lectureship, by the National Institute for Health Research, School for Primary Care Research (NIHR SPCR)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S1525861017303754
dc.rights © 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Antipsychotic en
dc.subject Prescribing behavior en
dc.subject Dementia en
dc.subject Nursing home en
dc.subject Qualitative research en
dc.subject Systematic review en
dc.title Influences on decision-making regarding antipsychotic prescribing in nursing home residents with dementia: a systematic review and synthesis of qualitative evidence en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Kieran A. Walsh, Clinical Gerontology & Rehabilitation, University College Cork, Cork, Ireland. +353-21-490-3000 en
dc.internal.availability Full text available en
dc.date.updated 2018-12-10T14:56:42Z
dc.description.version Accepted Version en
dc.internal.rssid 421662339
dc.internal.wokid WOS:000411335700016
dc.contributor.funder Health Research Board en
dc.contributor.funder Atlantic Philanthropies en
dc.contributor.funder National Institute for Health Research en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of the American Medical Directors Association en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress s.timmons@ucc.ie en
dc.internal.IRISemailaddress 108334854@umail.ucc.ie en
dc.internal.IRISemailaddress j.browne@ucc.ie en


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© 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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