In-hospital adverse drug reactions in hospitalised older adults - a systematic review

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dc.contributor.author Jennings, Emma L. M.
dc.contributor.author Murphy, Kevin D.
dc.contributor.author Gallagher, Paul F.
dc.contributor.author O'Mahony, Denis
dc.date.accessioned 2018-12-14T15:48:01Z
dc.date.available 2018-12-14T15:48:01Z
dc.date.issued 2018-10
dc.identifier.citation Jennings E., Murphy K., Gallagher P. and O'Mahony D (2018) In-hospital adverse drug reactions in hospitalised older adults - a systematic review, 14th International Congress of the EuGMS Berlin, 10-12 October, in Abstracts of the 14th International Congress of the European Geriatric Medicine Society, European Geriatric Medicine, 9 (supplement 1), p. s62. doi: 10.1007/s41999-018-0097-4 en
dc.identifier.volume 9 en
dc.identifier.issued Supplement 1 en
dc.identifier.startpage S62 en
dc.identifier.issn 1878-7649
dc.identifier.issn 1878-7657
dc.identifier.uri http://hdl.handle.net/10468/7224
dc.identifier.doi 10.1007/s41999-018-0097-4
dc.description.abstract Introduction: Studies indicate 1 in 4 older people experience hospital-related adverse drug reactions [ADRs]. This systematic-review aims to evaluate in-hospital ADRs in hospitalised older-adults in terms of incidence, prevalence, most commonly involved drug classes, severity, and consequences. Methods: Using PRISMA methodology [PROSPERO CRD42018079095], we searched PubMed, Embase, Ebsco-CINAHL, Cochrane Library, library hosted sources, Google scholar, and ‘grey’ literature, using terms; aged, ADRs, hospitalized, multi-morbid, polypharmacy and hospital-acquired. References of editorials and systematic reviews were hand searched. Studies of all languages and dates until 15/01/2018 were included. All studies reporting ADRs outcomes, ≥65 years, hospitalised at time of ADR occurrence were included. Two researchers screened all papers for inclusion, risk of bias and data extraction. Results: Initial search yielded 1721 abstracts, 200 underwent full text screening. 60 were potentially suitable for inclusion; 48 papers reported combined ages, 12 papers reported directly on ADRs in our age cohort [2 papers reported the same data]. 11 studies [4424 patients] were analysed; 24% [1064] experienced ADRs. 7 reported severity (n = 707); 31% [220] being severe. 5 reported on post-ADR outcomes i.e. length of stay [n = 3], death [n = 1] and functional decline [n = 1]. Frequency of culprit drug-groups were described in 6 [672 ADRs]; 43% [291] cardiovascular system, 17% [114] central nervous system, 16% [112] clotting pathways, 13% [90] anti-microbials. Conclusions: One in four over 65 years experience an ADR during hospitalisation, one third being severe, and almost half cardiovascular system drugs. Clinical outcomes associated with ADRs are generally poorly described in the literature. en
dc.description.abstract Poster presentation en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer en
dc.relation.ispartof 14th International Congress of the EuGMS
dc.relation.uri https://doi.org/10.1007/s41999-018-0097-4
dc.rights © European Geriatric Medicine Society 2018 en
dc.subject Geriatric medicine en
dc.subject Adverse effects of medication en
dc.subject ADR en
dc.subject Hospital acquired en
dc.title In-hospital adverse drug reactions in hospitalised older adults - a systematic review en
dc.type Conference item en
dc.internal.authorcontactother Kevin Murphy, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: kevin.murphy@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2018-12-13T08:06:25Z
dc.description.version Accepted Version en
dc.internal.rssid 457241815
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle European Geriatric Medicine en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.conferencelocation Berlin en
dc.internal.IRISemailaddress Kevin.Murphy@ucc.ie en
dc.internal.IRISemailaddress emma.jennings@ucc.ie en


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