Early-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation.

Show simple item record

dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Richardson, Rick
dc.date.accessioned 2019-02-06T09:57:59Z
dc.date.available 2019-02-06T09:57:59Z
dc.date.issued 2018-07-24
dc.identifier.citation Cowan, C. S. M. and Richardson, R. 'Early-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation', Developmental Psychobiology, In Press, doi: 10.1002/dev.21765 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 1098-2302
dc.identifier.uri http://hdl.handle.net/10468/7444
dc.identifier.doi 10.1002/dev.21765
dc.description.abstract Puberty marks the beginning of a period of dramatic physical, hormonal, and social change. This instability has made adolescence infamous as a time of "storm and stress" and it is well-established that stress during adolescence can be particularly damaging. However, prior stress may also shape the adolescent experience. In the present series of experiments, we observed sex-specific effects of early-life maternal separation stress on the timing of puberty onset in the rat. Specifically, stressed females exhibited earlier pubertal onset compared to standard-reared females, whereas stressed males matured later than their standard-reared counterparts. Further, we demonstrated that a probiotic treatment restores the normative timing of puberty onset in rodents of both sexes. These results are in keeping with previous findings that probiotics reverse stress-induced changes in learned fear behaviors and stress hormone levels, highlighting the remarkable and wide-ranging restorative effects of probiotics in the context of early-life stress. en
dc.description.sponsorship National Health and Medical Research Council (APP1031688); Petre Foundation (scholarship); University of New South Wales Canberra (UNSW Research Excellence Award) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://onlinelibrary.wiley.com/doi/abs/10.1002/dev.21765
dc.rights © 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Cowan CSM, Richardson R. Early‐life stress leads to sex‐dependent changes in pubertal timing in rats that are reversed by a probiotic formulation. Developmental Psychobiology, 2018;00: 1–9, which has been published in final form at https://doi.org/10.1002/dev.21765. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving." en
dc.subject Development en
dc.subject Early‐life stress en
dc.subject Maternal separation en
dc.subject Microbiota–gut–brain axis en
dc.subject Probiotic treatment en
dc.subject Puberty en
dc.subject Rats en
dc.subject Rodents en
dc.title Early-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation. en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Caitlin Cowan, Alimentary Pharmabotic Centre (Apc), University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitlin.cowan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-07-24
dc.date.updated 2019-02-05T15:05:50Z
dc.description.version Accepted Version en
dc.internal.rssid 472455935
dc.internal.pmid 30043520
dc.contributor.funder Australian Research Council en
dc.contributor.funder National Health and Medical Research Council en
dc.contributor.funder Petre Foundation en
dc.contributor.funder University of New South Wales en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Developmental psychobiology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress caitlin.cowan@ucc.ie en
dc.internal.bibliocheck In Pres, Feb 2019. Update Citation, Copyright statement, page numbers. Add vol, issue. en
dc.relation.project info:eu-repo/grantAgreement/ARC/Discovery Projects/DP150104835/AU/Discovery Projects - Grant ID: DP150104835/ en

Files in this item

This item appears in the following Collection(s)

Show simple item record

This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement