Treating generational stress: effect of paternal stress on development of memory and extinction in offspring is reversed by probiotic treatment

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dc.contributor.author Callaghan, Bridget L.
dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Richardson, Rick
dc.date.accessioned 2019-02-06T15:10:05Z
dc.date.available 2019-02-06T15:10:05Z
dc.date.issued 2016-09
dc.identifier.citation Callaghan, B. L., Cowan, C. S. M. and Richardson, R. (2016) 'Treating Generational Stress:Effect of Paternal Stress on Development of Memory and Extinction in Offspring Is Reversed by Probiotic Treatment', Psychological Science, 27(9), pp. 1171-1180. doi: 10.1177/0956797616653103 en
dc.identifier.volume 27 en
dc.identifier.issued 9 en
dc.identifier.startpage 1171 en
dc.identifier.endpage 1180 en
dc.identifier.issn 1467-9280
dc.identifier.uri http://hdl.handle.net/10468/7456
dc.identifier.doi 10.1177/0956797616653103
dc.description.abstract Early-life adversity is a potent risk factor for mental-health disorders in exposed individuals, and effects of adversity are exhibited across generations. Such adversities are also associated with poor gastrointestinal outcomes. In addition, emerging evidence suggests that microbiota-gut-brain interactions may mediate the effects of early-life stress on psychological dysfunction. In the present study, we administered an early-life stressor (i.e., maternal separation) to infant male rats, and we investigated the effects of this stressor on conditioned aversive reactions in the rats' subsequent infant male offspring. We demonstrated, for the first time, longer-lasting aversive associations and greater relapse after extinction in the offspring (F1 generation) of rats exposed to maternal separation (F0 generation), compared with the offspring of rats not exposed to maternal separation. These generational effects were reversed by probiotic supplementation, which was effective as both an active treatment when administered to infant F1 rats and as a prophylactic when administered to F0 fathers before conception (i.e., in fathers' infancy). These findings have high clinical relevance in the identification of early-emerging putative risk phenotypes across generations and of potential therapies to ameliorate such generational effects. en
dc.description.sponsorship National Health and Medical Research Council Project grant ((APP1031688); Early Career Fellowship); Australian Postgraduate Award; Petre Foundation (scholarship); en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Sage en
dc.relation.uri https://journals.sagepub.com/doi/abs/10.1177/0956797616653103
dc.rights © 2016 Sage Publications. Reprinted by permission of SAGE Publications. en
dc.subject Maternal separation en
dc.subject Extinction en
dc.subject Pavlovian conditioning en
dc.subject Infantile amnesia en
dc.subject Inheritance en
dc.subject Generational effects en
dc.subject Probiotic en
dc.title Treating generational stress: effect of paternal stress on development of memory and extinction in offspring is reversed by probiotic treatment en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Caitlin Cowan, Alimentary Pharmabotic Centre (APC), University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitlin.cowan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-02-05T16:57:11Z
dc.description.version Accepted Version en
dc.internal.rssid 472455944
dc.internal.pmid 27422874
dc.contributor.funder Australian Research Council en
dc.contributor.funder National Health and Medical Research Council en
dc.contributor.funder Petre Foundation en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Psychological Science en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress caitlin.cowan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/ARC/Discovery Projects/DP0985554/AU/Developmental analysis of extinction of learned fear in rats/ en
dc.relation.project info:eu-repo/grantAgreement/ARC/Discovery Projects/DP120104925/AU/Effects of early life trauma on fear memory and fear extinction in rats/ en


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