A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

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A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

Byrne, Peter A.; Rajendran, Kamalraj V.; Muldoon, Jimmy; Gilheany, Declan G.
Date: 2012-03-05
Copyright: © The Royal Society of Chemistry 2012
Related: https://pubs.rsc.org/en/Content/ArticleLanding/2012/OB/c2ob07074j
Citation: Byrne, P. A., Rajendran, K. V., Muldoon, J. and Gilheany, D. G. (2012) 'A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions', Organic & Biomolecular Chemistry, 10(17), pp. 3531-3537. doi: 10.1039/C2OB07074J
Published Version: 10.1039/C2OB07074J

Abstract:

A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.

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