A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

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dc.contributor.authorByrne, Peter A.
dc.contributor.authorRajendran, Kamalraj V.
dc.contributor.authorMuldoon, Jimmy
dc.contributor.authorGilheany, Declan G.
dc.contributor.funderIrish Research Council for Science, Engineering and Technologyen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-04-04T13:54:43Z
dc.date.available2019-04-04T13:54:43Z
dc.date.issued2012-03-05
dc.date.updated2019-03-26T18:14:12Z
dc.description.abstractA mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.en
dc.description.sponsorshipIrish Research Council for Science, Engineering and Technology (EMBARK Scholarship)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationByrne, P. A., Rajendran, K. V., Muldoon, J. and Gilheany, D. G. (2012) 'A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions', Organic & Biomolecular Chemistry, 10(17), pp. 3531-3537. doi: 10.1039/C2OB07074Jen
dc.identifier.doi10.1039/C2OB07074Jen
dc.identifier.endpage3537en
dc.identifier.issn1477-0520
dc.identifier.journaltitleOrganic and Biomolecular Chemistryen
dc.identifier.startpage3531en
dc.identifier.urihttps://hdl.handle.net/10468/7715
dc.identifier.volume10en
dc.language.isoenen
dc.publisherRoyal Society of Chemistry (RSC)en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Frontiers Programme (RFP)/08/RFP/CHE1251/IE/P-Stereogenic Phosphorus Compounds as Components of Nucleoside Prodrugs/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/09/IN.1/B2627/IE/Construction of P-Stereogenic Components of ProTide Drug Candidates/en
dc.relation.urihttps://pubs.rsc.org/en/Content/ArticleLanding/2012/OB/c2ob07074j
dc.rights© The Royal Society of Chemistry 2012en
dc.subjectPhosphorus compoundsen
dc.subjectChlorine compoundsen
dc.subjectPhosphorusen
dc.subjectCrude productsen
dc.subjectOxalyl chlorideen
dc.subjectPhosphine oxidesen
dc.titleA convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactionsen
dc.typeArticle (peer-reviewed)en
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