A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

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Date
2012-03-05
Authors
Byrne, Peter A.
Rajendran, Kamalraj V.
Muldoon, Jimmy
Gilheany, Declan G.
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Volume Title
Publisher
Royal Society of Chemistry (RSC)
Published Version
10.1039/C2OB07074J
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Abstract
A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.
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Keywords
Phosphorus compounds , Chlorine compounds , Phosphorus , Crude products , Oxalyl chloride , Phosphine oxides
Citation
Byrne, P. A., Rajendran, K. V., Muldoon, J. and Gilheany, D. G. (2012) 'A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions', Organic & Biomolecular Chemistry, 10(17), pp. 3531-3537. doi: 10.1039/C2OB07074J
Link to publisher’s version
https://pubs.rsc.org/en/Content/ArticleLanding/2012/OB/c2ob07074j
URI
https://hdl.handle.net/10468/7715
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Chemistry - Journal Articles
Copyright
© The Royal Society of Chemistry 2012