Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa

Fitzgerald, Cormac Brian; Shkoporov, Andrey N.; Sutton, Thomas D. S.; Chaplin, Andrei V.; Velayudhan, Vimalkumar; Ross, R. Paul; Hill, Colin

Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa

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s12864-018-5313-6.pdf(16.32 MB)

Published version

Date

2018-12-14

Authors

Fitzgerald, Cormac Brian

Shkoporov, Andrey N.

Sutton, Thomas D. S.

Chaplin, Andrei V.

Velayudhan, Vimalkumar

Ross, R. Paul

Hill, Colin

Publisher

BMC part of Springer nature

Published Version

10.1186/s12864-018-5313-6

Abstract

Faecalibacterium prausnitzii is a ubiquitous member of the human gut microbiome, constituting up to 15% of the total bacteria in the human gut. Substantial evidence connects decreased levels of F. prausnitzii with the onset and progression of certain forms of inflammatory bowel disease, which has been attributed to its anti-inflammatory potential. Two phylogroups of F. prausnitzii have been identified, with a decrease in phylogroup I being a more sensitive marker of intestinal inflammation. Much of the genomic and physiological data available to date was collected using phylogroup II strains. Little analysis of F. prausnitzii genomes has been performed so far and genetic differences between phylogroups I and II are poorly understood.

Keywords

Faecalibacterium prausnitzii , Ruminococcaceae , Human gut microbiota , IBD , Genome shuffling

Citation

Fitzgerald, C.B., Shkoporov, A.N., Sutton, T.D., Chaplin, A.V., Velayudhan, V., Ross, R.P. and Hill, C., 2018. Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa. BMC genomics, 19(1), 931 (19pp) DOI: 10.1186/s12864-018-5313-6