Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa

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dc.contributor.author Fitzgerald, Cormac Brian
dc.contributor.author Shkoporov, Andrey N.
dc.contributor.author Sutton, Thomas D. S.
dc.contributor.author Chaplin, Andrei V.
dc.contributor.author Velayudhan, Vimalkumar
dc.contributor.author Ross, R. Paul
dc.contributor.author Hill, Colin
dc.date.accessioned 2019-05-22T12:00:59Z
dc.date.available 2019-05-22T12:00:59Z
dc.date.issued 2018-12-14
dc.identifier.citation Fitzgerald, C.B., Shkoporov, A.N., Sutton, T.D., Chaplin, A.V., Velayudhan, V., Ross, R.P. and Hill, C., 2018. Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa. BMC genomics, 19(1), 931 (19pp) DOI: 10.1186/s12864-018-5313-6 en
dc.identifier.volume 19 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 20 en
dc.identifier.issn 1471-2164
dc.identifier.uri http://hdl.handle.net/10468/7965
dc.identifier.doi 10.1186/s12864-018-5313-6 en
dc.description.abstract Faecalibacterium prausnitzii is a ubiquitous member of the human gut microbiome, constituting up to 15% of the total bacteria in the human gut. Substantial evidence connects decreased levels of F. prausnitzii with the onset and progression of certain forms of inflammatory bowel disease, which has been attributed to its anti-inflammatory potential. Two phylogroups of F. prausnitzii have been identified, with a decrease in phylogroup I being a more sensitive marker of intestinal inflammation. Much of the genomic and physiological data available to date was collected using phylogroup II strains. Little analysis of F. prausnitzii genomes has been performed so far and genetic differences between phylogroups I and II are poorly understood. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BMC part of Springer nature en
dc.relation.uri https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-5313-6
dc.rights © 2018 The Author(s) en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Faecalibacterium prausnitzii en
dc.subject Ruminococcaceae en
dc.subject Human gut microbiota en
dc.subject IBD en
dc.subject Genome shuffling en
dc.title Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Colin Hill, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: c.hill@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder European Regional Development Fund en
dc.contributor.funder Janssen Biotech en
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Genomics en
dc.internal.IRISemailaddress c.hill@ucc.ie en
dc.identifier.articleid 931 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Spokes Programme/14/SP APC/B3032/IE/Gut Phageomics - Phage as diagnostics and/or therapeutics in IBD/ en


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